For all Vicente del Bosque's confidence that he has the right balance of experience and youth to return Spain to their familiar place on the winner's rostrum, questions remain about his best starting line-up ahead of Euro 2016.
Following is a match by match look at the English Premier League's weekend fixtures:
In the middle of Chelsea's most chaotic season in decades, a semblance of normality has broken out.
Barcelona goalkeeper Victor Valdes is likely to be out of action until the end of the year after suffering a calf strain during Spain's surprise defeat by South Africa on Tuesday, the club said in a statement on their website.
Chelsea moved 12 points clear of Arsenal, who suffered their fourth defeat in nine league matches, while fourth-placed Liverpool fell 13 point adrift after their wretched 2017 continued with a shock 2-0 defeat at resurgent Hull City.
Here is a look at what happened in their previous Euro semis...
Fans are openly speculating that owner Roman Abramovich, a man who places notoriously high demands on his managers, could call time on Jose Mourinho's second spell at Stamford Bridge if Liverpool can inflict another defeat on the champions.
Liverpool's hopes of qualifying for the Champions League all but ended.
The much-anticipated clash between Liverpool and ManchesterCity at Anfield on Saturday looks like a knockout to determine who can challenge Chelsea for the Premier League title.
Chelsea came from behind to secure a 3-1 win at Manchester City and forge further clear at the top of the Premier League as a dramatic top-of-the-table clash ended in a mass brawl and two City players being sent off on Saturday.
News of all that's transpired on and off the football field
Check out the top footballers of the weekend...
The omens are good for a Chelsea side heading into Christmas top of the Premier League tree but manager Jose Mourinho does not want to give title rivals Manchester City any reason to cheer over the festive season. Check out the big games on Boxing Day.
Manchester United's top-four aspirations suffered a setback as Louis van Gaal's side were blown away 3-0 by Everton.
Chelsea put all their struggles away and looked like a renewed squad, stamping their class over Crystal Palace in their English Premier League match at the Selhurst Park on Sunday.
Diego Costa was on target again as Chelsea overcame a defensive West Bromwich Albion 1-0 to return to the top of the Premier League with their ninth victory in a row on Sunday. The Spaniard's second-half strike sent the Blues three points clear of Arsenal, who had taken the overall lead on goals scored on Saturday after seeing off Stoke City 3-1 at the Emirates.
Chelsea may have restored some breathing space over Manchester City with a 2-0 win over Newcastle United on Saturday but they have not regained the form that made them runaway title favourites earlier in the season.
If, as former British Prime Minister Harold Wilson once said, a week is a long time in politics, four and a half months in football clearly represents an eternity.
Jose Mourinho says he is going through the worst period of his managerial career.
Images from the English Premier League matches played on Saturday.
Chelsea came from behind to beat Leicester City 3-1 on Wednesday and move to within one win of clinching the Premier League title for the first time in five years.
Messi opened the scoring after two minutes and eight seconds, the quickest goal of his career, slipping the ball through Thibaut Courtois' legs from a tight angle.
Romelu Lukaku scored two goals for Everton, one demonstrating rare strength and skill, to knock his old side Chelsea out of the FA Cup 2-0 in a dramatic quarter-final featuring two red cards on Saturday. All the frantic action happened in the final 13 minutes with Chelsea striker Diego Costa and Everton midfielder Gareth Barry sent off but their dismissals only came after Lukaku's brilliance had put the tie beyond doubt. The powerful Belgium striker, who never fitted in at Stamford Bridge and was sold to the Merseysiders for 28 million pounds ($40.28 million) two years ago, proved irresistible with his late five-minute double, especially with a first goal destined to go down in Goodison Park folklore. As the game meandered towards a replay, Lukaku conjured a 77th-minute goal from nowhere, muscling past two defenders on the left, powering into the box and, after some nifty footwork to bamboozle Gary Cahill, firing in a left-foot effort. Everton manager Roberto Martinez hailed it "one of the great goals we will see in the FA Cup".
'You cannot sack all the players so sack the manager -- whether right or wrong'
Holders Spain lost for the first time in 15 matches at the European Championship finals on Tuesday when Croatia beat them 2-1 to win Group D at Euro 2016.
News of all that's transpired on and off the football field
Spain fullback Mario Gaspar scored with a stunning volley and midfielder Santi Cazorla added a late goal as the European champions handed England a chastening 2-0 defeat in a friendly between the continental heavyweights on Friday.
A summary of the results of the major European football league matches on the weekend.
Luis Aragones, the coach of Spain's 2008 European Championship-winning side, has died at the age of 75, the Spanish Football Federation (RFEF) announced on Saturday.
City's Aguero doubtful starter for Watford trip
From the planet's costliest player Neymar to 'tiki-taka' kings Xavi and Iniesta to the ultimate sorcerer Ronaldinho, the FIFA Under-17 World Cup has been the cradle for many of world football's household names.
Arsene Wenger often says he has no time to look back because he is so focused on the future but he spent a minute reminiscing on Friday on the 10th anniversary of the defeat to Manchester United that ended Arsenal's famous 49-match unbeaten run.
Javier Ceppi, Tournament Director of the 2017 Under-17 football World Cup, which India will host, says the success of the event depends on the country's fans. Laxmi Negi reports.
Leicester go five clear after win at Everton
If you ask Barcelona and Spain fans about their most cherished footballing memories over the past decade the chances are they will involve an exquisite intervention from midfield maestro Xavi.
Chelsea look capable of beginning a period of sustained domestic dominance. The average age of their squad is 26.9 -- with most of their key players in or approaching their prime years.
Aritz Aduriz scored his first goal for Spain at the age of 35 to give the European champions a fortuitous 1-1 draw away to Italy in a Euro 2016 warm-up for both teams on Thursday.
"I think Hazard will be able to get a breather every now and again now," said Hudson.
Chelsea overpowered West Ham United and Manchester City outclassed West Bromwich Albion as the Premier League title rivals signalled their intent at the start of a hectic holiday programme on Friday.
Real Madrid's bid to land Gareth Bale from Tottenham Hotspur for a world record fee in the region of 100 million euros is out of place in the current economic climate, Barcelona coach Gerardo Martino said on Saturday.