And champions Arsenal face Blackburn Rovers in next month's FA Cup semi-finals in Cardiff.
After bagging the League Cup, being locked in a titanic battle with Liverpool for the Premier League title and in the Champions League quarter-finals, Pep Guardiola's side remain on course for an unprecedented clean sweep.
Monday's draw gave Arsenal the hardest possible obstacle in their bid to become the first club since Blackburn Rovers in 1886 to win the FA Cup three years in succession.
A look at some of the major disasters in soccer stadiums over the last 40 years after at least eight people were killed and 38 injured in a stampede at the Yaounde Olembe Stadium in Cameroon on Monday before their Africa Cup of Nations round of 16 game against Comoros.
The Franchman is likely to miss the match on Wednesday due to a groin injury.
The defeat foiled Chelsea's bid for the league-Cup double.
The English clubs were paired in the FA Cup semi-final draw on Friday
Crystal Palace set up a repeat of the 1990 FA Cup final against Manchester United after Yannick Bolasie and Connor Wickham securd a 2-1 victory over Watford at Wembley on Sunday.
Europa League kings Sevilla breezed past Manchester United into the semi-finals of their favourite competition as Youssef En Nesyri scored twice
Manchester United coach Ole Gunnar Solskjaer berated his team for their under par performance in the first half in their FA Cup semi-final first leg loss to cross-town rivals Manchester United
Chelsea closed the gap on leaders Arsenal to four points on Saturday with a 1-0 win at Tottenham Hotspur in the English premier league.
Thierry Henry and Sol Campbell will miss Arsenal's FA Cup semi-final against Blackburn Rovers due to injury
Arsenal's top scorer Thierry Henry has been ruled out of their FA Cup semi-final against Blackburn Rovers on Saturday due to a groin injury.
Second-tier Reading booked an FA Cup semi-final meeting with holders Arsenal.
IMAGES from the EPL matches played on Wednesday.
Elite sport in Britain returned without fans last month after a near three-month shutdown due to the COVID-19 pandemic and the government is set to allow spectators at carefully selected trial events from late July to early August.
Arsenal started the season strongly with a six-game winning streak that lifted them to second position in the league but have since faded and are seven points behind fourth-placed City with just two wins in their last six league games.
Watford's hopes of avoiding relegation suffered a double blow on Tuesday when they were thrashed 4-0 at home by Manchester City and then slipped into the Premier League relegation zone after fellow strugglers Aston Villa beat Arsenal in the late game.
The 96 soccer fans who died in Britain's worst-ever sporting disaster, the 1989 Hillsborough football stadium crush, were unlawfully killed, with police failures to blame, a jury hearing inquests into the death concluded on Tuesday.
Guardiola upbeat despite Man City setback at Tottenham
Late goals from Eden Hazard and Nemanja Matric sealed a 4-2 victory for Chelsea over London rivals Tottenham Hotspur in a rip-roaring FA Cup semi-final at Wembley on Saturday.
Pep Guardiola is pleased with the Premier League side's improvement and form over the past two months but will not make any premature comparison with his former clubs.
The France international has scored five goals and provided 10 assists in 23 Premier League appearances this season but has been criticised on multiple occasions as United fell behind ManchesterCity in the title race.
Images from Saturday's action in the Premier League.
FA Cup holders Arsenal were taken to extra time before a horrendous error by Reading goalkeeper Adam Federici brought the Championship side's dream to an end in a 2-1 semi-final defeat on Saturday.
Rediff.com encapsulates all the sporting action from the past week in this eye-catching photo feature.
Chelsea have enough experience to keep their composure in the title race after Sunday's 2-0 defeat at Manchester United cut their lead at the top of the Premier League table to four points with six games left, goalkeeper Asmir Begovic has said.
There were a few nerves at the end but Liverpool set up a Champions League semi-final with Spain's Villarreal after Roberto Firmino scored twice in a 3-3 second-leg draw with Benfica on Wednesday to ensure a 6-4 aggregate win.
Daniel Ceballos fired Arsenal into the FA Cup semi-finals with a stoppage-time goal that sealed a 2-1 win over Sheffield United
Liverpool are calling on football fans from around the world to show their support for the 25th anniversary of the Hillsborough disaster by sending in club scarves.
Former Liverpool players will return to Anfield for a special one-off charity match to mark the 25th anniversary of the Hillsborough disaster in April, the club has announced.
Ronaldo back for Man Utd but injured Shaw faces weeks out