Barcelona travel to newly-promoted Osasuna without their first choice front line.
Chelsea have signed Germany's highly-rated attacking midfielder Kai Havertz from Bundesliga side Bayer Leverkusen on a five-year contract, the Premier League club announced on Friday.
London sides Tottenham Hotspur and Arsenal made winning starts as did fellow Premier League club Leicester City.
Barcelona wasted a golden opportunity to extend their lead at the top of LaLiga as they were shocked 1-0 at lowly Almeria on Sunday thanks to a first-half strike by El Bilal Toure.
Seven-time European champions AC Milan hit back from two goals down against Celtic to claim a 4-2 victory that sent them into the Europa League knockout phase on Thursday as they were among 14 teams to progress in Europe's second-tier competition.
Images from the Champions League football matches played on Wednesday night.
Champions Barcelona lost 2-0 at Celta Vigo while Getafe earned an important 2-0 win over Girona in their bid to secure Champions League qualification.
Images from soccer matches played across Europe on Saturday.
A round-up of Wednesday's action in the UEFA Champions League.
Here are five talking points from the weekend in La Liga.
Ajax, four-times European Cup winners who are in the knockout stages for the first time in 13 years, have enhanced their reputation as a talent factory due to the rise of homegrown Dutch players Frenkie de Jong and Matthijs de Ligt.
Champions Barcelona moved five points clear at the top of La Liga with a 2-1 win at Getafe, while Real Madrid fell to a 2-0 defeat by Real Sociedad.
IMAGES from the La Liga matches played on Sunday
Atletico Madrid crashed out of the Copa del Rey to Girona on Wednesday following a highly entertaining 3-3 draw at home to the Catalan side, who sneaked through to the quarter-finals on away goals after the tie finished 4-4 on aggregate.
Leicester City's Kelechi Iheanacho scored two poacher's goals as they beat Manchester United 3-1 in their FA Cup quarter-final on Sunday to set up a last-four clash against Southampton.
Real Madrid dropped points for the third time in seven games since Zinedine Zidane's return as they were held to a 0-0 draw away to Getafe in La Liga on Thursday, which harmed their neighbours' hopes of a top-four finish.
Liverpool manager Juergen Klopp is expecting his toughest test yet in a Merseyside derby when his side face local rivals Everton in the Premier League on Sunday.
Lionel Messi dragged a nervous Barcelona to a 1-0 win at home to Levante in La Liga, while Cristiano Ronaldo converted two late penalties on his 100th appearance for Juventus in all competitions as the Serie A titleholders ground out a 3-1 win away to a dogged Genoa side.
Karim Benzema netted a second-half hat-trick as Real Madrid got back to winning ways with a 3-0 victory over Athletic Bilbao in La Liga on Sunday.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
Images from Champions League matches played across Europe on Tuesday