Barcelona have completed their business in the latest transfer window and the Spanish and European champions' squad is now "closed", president Josep Bartomeu said on Thursday.
Here are five talking points from the weekend in La Liga.
Barca must beat Villareal on the weekend if they are to stand a chance of overhauling Real in the run in.
Real Madrid coach Zinedine Zidane is under pressure to break up his misfiring attacking trio of Cristiano Ronaldo, Karim Benzema and Gareth Bale when he takes the La Liga leaders to Alaves on Saturday.
Barcelona are in the middle of an injury crisis as they head to Valencia for Saturday's La Liga game looking to keep up with pacemaking pair Atletico Madrid and Real Madrid. Without injured goalkeeper Jasper Cillessen and right back Sergi Roberto for the last two games, Barca will also be missing defenders Jordi Alba and Gerard Pique after both were hurt in Wednesday's 4-0 win over Manchester City in the Champions League. Pique sprained his right ankle while Alba injured his left hamstring and both are out until November.
Barcelona midfielder Xavi raised the King's Cup aloft alongside Andres Iniesta in his final appearance at the Camp Nou on Saturday and now victory in the Champions League would make it a perfect send-off for the club legend.
Images from football matches played in La Liga and Serie A in Spain and Italy on Wednesday.
Karim Benzema made history at Real Madrid, the battle for the top four continues to heat up
La Liga leaders Barcelona drew 0-0 at Huesca on Saturday and are nine points clear of second-placed Atletico Madrid, who cut the gap by beating Celta Vigo 2-0.
The win increased Zinedine Zidane's side's advantage at the top of the standings to six points
Real Madrid beat Leganes 2-1 in La Liga on Saturday after coach Zinedine Zidane heavily rotated his side in preparation for Tuesday's Champions League semi-final second leg against Bayern Munich, including leaving out top-scorer Cristiano Ronaldo.
Real fought back after a calamitous own goal from keeper Keylor Navas gave Betis the lead in the 25th minute, just after the Costa Rican escaped a possible red card. Cristiano Ronaldo pulled the hosts level in the 41st with a diving header.
Gary Neville's disappointing start as Valencia coach continued when the ambitious Singapore-owned club drew 2-2 at home to lowly Rayo Vallecano in La Liga on Sunday, prompting more rumblings of discontent from the fans.
'I haven't lost any strength in the last four days and in one sense I feel a little relieved but focused on the objectives we set for ourselves at the start of the season'
Barcelona beat local rivals Espanyol 2-0 in the Catalan derby on Saturday to maintain their 10 point lead at the top of La Liga, while Real Madrid scraped a 3-2 win against bottom side Huesca on Sunday.
It is a scenario few could have foreseen after Real won a Liga and Champions League double last term and began this season so convincingly.
If Atletico Madrid's 2013 King's Cup triumph was a shock and their 2013-14 La Liga title a surprise, few would raise an eyebrow if Diego Simeone's ruthlessly efficient side were to win another major trophy.
Edinson Cavani scored early for Paris St Germain but a series of wasted chances came back to haunt them as Ajax Amsterdam equalised late to deny the French a winning start on the road in a 1-1 draw in Champions League Group F on Wednesday.
Marcelino dismissed but Valencia keep pressure on Barcelona
Real Madrid, Barcelona and Atletico Madrid, find themselves in the bizarre situation of having made poor starts to the campaign
La Liga leaders Real Madrid suffered a surprise 1-0 defeat at mid-table Athletic Bilbao on Saturday after a bullet header from Aritz Aduriz in the first half secured the points.
Napoli went down 3-1 at home to RB Leipzig, Arsenal and AC Milan enjoyed comfortable away wins, and Borussia Dortmund's Michy Batshuayi scored twice to secure a 3-2 victory in Europa League last 32, first leg action
Villarreal tightened their grip on fourth place in La Liga when Nigerian forward Ikechukwu Uche's last-gasp strike snatched a 1-0 win at fellow promoted side Elche on Monday.
The numbers behind Saturday's La Liga "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT).
Barcelona, Atletico Madrid and Real Madrid resume a nail-biting La Liga title race on Saturday after all notched up victories on Wednesday. Leaders Barcelona, who ended a four-game winless streak by hammering Deportivo La Coruna 8-0 away from home, host struggling Sporting Gijon on Saturday. Atletico battled to a 1-0 win at Athletic Bilbao to stay level on 79 points with Barcelona, who top the table with a superior head-to-head record and host Malaga. Real stayed one point behind their title rivals after beating Villarreal 3-0 and are expected to be without top scorer Cristiano Ronaldo for their visit to struggling neighbours Rayo Vallecano. The Portuguese forward was unable to finish the game against Villarreal after suffering cramp in stoppage time but eased concerns he had suffered a serious injury.
Lionel Messi scored a 50th freekick goal for Barcelona as he led his side to a quick-fire comeback to win 3-2 at Valencia on Sunday and keep the pressure on La Liga title rivals Atletico Madrid and Real Madrid.
Jose Callejon took advantage of Napoli's numerical advantage in the 48th minute of the playoff round second leg tie, handing them an away goal which, added to their 2-0 win from the first leg, effectively ended Nice's challenge as it left the French side needing to score four goals.
Barca, who were without injured talisman Lionel Messi, started on the back foot and fell behind when Nabil Fekir netted with a sublime angled strike in the 15th minute. Griezmann, who joined Barca last month from rivals Atletico Madrid, scored four minutes before halftime to level the scores.
Barcelona coach Luis Enrique said he was shocked by the wild knee-high challenge on world player of the year Lionel Messi that triggered a straight red card for Atletico Madrid's Brazilian defender Filipe Luis on Saturday. The coach, whose side won 2-1 at home to go three points clear in La Liga, protested angrily on the touchline after the left back's studs-up tackle against the Argentine forward shortly before half time. "Did you see my reaction? Then you can imagine what I was thinking. It shocked me but I am not going to go into details about it," he told a news conference at the Nou Camp.
Barcelona coach Luis Enrique is expecting another gruelling game at Athletic Bilbao when the La Liga champions visit San Mames on Sunday.
AC Milan, Villarreal and Nice reached the knockout stage of the Europa League after posting wins on Thursday in the penultimate round of the group stage.
News of all that transpired on and off the football field.
With a fifth world player of the year award safely tucked away in the trophy cabinet, Lionel Messi can set his sights on one of the next milestones in his remarkable career: reaching 500 goals for club and country. The Barcelona and Argentina forward can add to his jaw-dropping tally of 479 in 609 official games -- 430 for Barca and 49 for his national team -- in Sunday's La Liga match at home to Athletic Bilbao. The 28-year-old from Rosario, who picked up the FIFA Ballon d'Or on Monday, is looking close to his best following a two-month injury layoff late last year and netted a hat-trick when second-placed Barca crushed Granada 4-0 at the Nou Camp last weekend in their most recent outing in Spain's top flight.
Fresh from propelling Barcelona to their fifth trophy of 2015, their prolific strikes are now seeking to break the Spanish record of goals in a calendar year when they play Real Betis on Wednesday.
Valencia turned up the heat on Atletico Madrid in the fight for third place in La Liga when a 3-0 derby victory at home to Levante on Monday lifted the Singapore-owned club to within a point of the champions with seven games left.
Villarreal's slide continued as a Diego Castro header gave Getafe a 1-1 draw in La Liga on Sunday but the match was overshadowed by a serious injury to Mateo Musacchio.
Outgoing Spain coach Vicente del Bosque has no regrets as he prepares to leave his post at the end of July after eight years in charge during which they won the World Cup and Euro 2012.
Atletico Madrid turned up the heat on champions Barcelona when they fought back to secure a 2-1 win at home to Athletic Bilbao in La Liga on Sunday as Real Madrid slipped off the pace with a 1-0 loss at Villarreal.
Luis Suarez scored a hat-trick and Lionel Messi bagged a brace as Barcelona thrashed bottom side Cordoba 8-0 on Saturday to move a step closer to their fifth La Liga title in seven years.
Argentina's Lionel Messi and Carlos Tevez, English third tier player David Hall and U.S. women's international Carli Lloyd were among players included on the shortlist for FIFA's goal of the year award on Friday.
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