Former World No. 1 India's Kidambi Srikanth bows out of US Open badminton tournament
Olympic medallist P V Sindhu is also missing in action as she recovers from an injury.
However, a tough contest awaits the former world No. 1 as he faces top seed Kenta Nishimoto of Japan next.
Two-time Olympic medallist P V Sindhu rallied from a game down to eke out a hard-fought win over Thailand's Supanida Katethong and enter the semi-finals of the Syed Modi International Super 300 tournament, in Lucknow, on Friday.
Sindhu took just 33 minutes to get the better of American Lauren Lam 21-16 21-13
Former world No. 1 Saina, who missed a lot of tournaments last year due to multiple injuries, moved to the second round after her opponent, Czech Republic's Tereza Svabikova, suffered a back injury and retired mid-way while trailing 20-22, 0-1 in an opening round match.
Seventh seeded Indians Ishaan Bhatnagar and Tanisha Crasto clinched the mixed doubles title with a straight-games' win over compatriots T Hema Nagendra Babu and Srivedya Gurazada.