Liverpool had to be satisfied with a 1-1 Premier League draw at Arsenal on Saturday as their usually prolific attacking trio were well shackled by their improving hosts.
With Liverpool still to visit Chelsea, who trail them by nine points with two games in hand, Juergen Klopp's side may have to beat Brighton & Hove Albion on May 13 and rely on their superior goal difference to qualify for the Champions League, assuming they do not secure it by winning this year's trophy.
Knee injuries have sidelined him for large parts of this season, however, and the Belgium international has started only four Premier League games.
A round-up of Wednesday's night's UEFA Chmpions League matches.
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Manchester City's all-conquering season reached new peaks as Sergio Aguero became the club's all-time top scorer with a decisive goal in a thrilling 4-2 victory at Napoli that put them into the Champions League last 16 on Wednesday.
A summary of Tuesday's group matches in the UEFA Champions League.