The 34 year old is the first female South actor to feature on the magazine's cover.
Vogue India's October cover features three young superstars from South Cinema.
What's interesting is Nayanthara is sharing space with Dulquer Salmaan and Mahesh Babu.
In the special issue, the successful trio reveal how their decisions have shaped the industry, their fashion choices and more.
Check out the hot magazine cover and Nayanthara's gorgeous pictures from the photo shoot.