Lyon sealed top spot in the Europa League standings while Roma survived a red-card scare to reach the last 16 on a chaotic final league-phase night.
Aston Villa secured a 2-1 victory at Basel on Thursday, with goals from Evann Guessand and Youri Tielemans keeping their Europa League campaign on a strong footing.
Lyon thump Maccabi Tel Aviv to go top, Forest keep on winning
Arsenal sailed through the Europa League group stages, winning five of their six group matches and take on Sporting next, who overcame Denmark's FC Midtjylland in their playoff.
Danish league leaders FC Midtjylland installed giant screens in the parking lot of their MCH Arena to allow fans to watch matches from the their cars from the more than 2,000 available spaces.
Manchester United captain Wayne Rooney has been left out of the 18-man squad travelling to face Danish side FC Midtjylland in the Europa League on Thursday, the Premier League club said on their website (www.manutd.com). With United fifth in the league table, six points off the top-four, the 30-year-old striker recently said that winning the Europa League or the FA Cup could save their disappointing season. Combative midfielder Marouane Fellaini was another notable absentee and full back Matteo Darmian will not be involved after dislocating his shoulder during Saturday's 2-1 league defeat by Sunderland.
Defending champions Bayern Munich must face Diego Simeone's Atletico Madrid after they were drawn together in Champions League Group A alongside Salzburg and Lokomotiv Moscow.
Dinamo Bucharest sent Everton crashing with a 5-1 defeat in the first leg of their UEFA Cup first round tie.
Manchester United captain Wayne Rooney has suffered a knee injury and faces a spell on the sidelines, manager Louis van Gaal said on Wednesday. The 30-year-old was left out of the 18-man squad that travelled to face FC Midtjylland in the Europa League on Thursday and Van Gaal explained why after arriving in Denmark. "We have 13 players injured and Wayne is one of them,"
Former European champions Steaua Bucharest and English Premier League Southampton suffered shock defeats by Scandinavian teams in Europa League qualifiers on Thursday.
Manchester United and Liverpool, English football's two most decorated clubs, were drawn together in the last 16 of the Europa League on Friday.
Manchester United must learn to ignore their critics as their performances may have been affected by the intense scrutiny the team have been under throughout the campaign, manager Louis van Gaal said on Wednesday.
Manchester United need to win trophy to save season, says Wayne Rooney.
Manchester United manager Louis van Gaal admitted it would be very hard to finish in the top four after his team's insipid 2-1 loss at Sunderland in the Premier League on Saturday.
Manchester United's hopes of salvaging their season in the Europa League suffered a stinging setback when they lost 2-1 at Danish side Midtjylland in the first leg of their last-32 clash on Thursday.
'My hope for Rashford, and it is a vain hope, is that he will be allowed to develop in peace and it won't suddenly be a question of, 'You have scored two goals for Man United and you're going to be the next Cristiano Ronaldo' or every time he has two or three bad games he is a flash in the pan'
Denmark's Superliga to resume on May 28 says Danish League Association
Four-time European champions Ajax Amsterdam were knocked out of the Champions League in the third qualifying round on Tuesday after a dramatic 3-2 defeat at home to unsung Rapid Vienna.
Long throw-ins a perfect secret set-piece weapon
The 22-year-old was named in Arnold's first squad last week as the new coach looks to regenerate the team with youth after the Socceroos' group stage exit at the World Cup.
Liverpool thrashed Atalanta 5-0, Real Madrid boosted their chances of reaching the Champions League knockout stages with a 3-2 home victory over Inter Milan and Bayern Munich came from behind to crush RB Salzburg 6-2.
Liverpool laboured to a 2-0 win over Denmark's Midtjylland on Tuesday as a goal from Diogo Jota and a Mohamed Salah penalty secured a hard-fought Champions League Group D victory at Anfield.
IMAGES from the Champions League matches played on Wednesday.
Manchester United flirted with calamity before coasting into the Europa League last 16 as debutant Marcus Rashford helped them overcome an early blow with two goals in a 5-1 home victory over Midtjylland on Thursday.
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.