Villarreal's slide continued as a Diego Castro header gave Getafe a 1-1 draw in La Liga on Sunday but the match was overshadowed by a serious injury to Mateo Musacchio.
The Villarreal defender was carried off on a stretcher with 13 minutes to go after his ankle buckled when he was running for the ball.
He has since been successfully operated on in hospital after suffering a dislocation and break.
"The game comes second. I didn’t think it was so serious but when I saw the blood I was shocked," Villarreal coach Marcelino said.
"It is a serious injury and we will have to see what happens next. It really is terrible what has happened."
An Ikechukwu Uche penalty, after he himself was fouled by Medhi Lacen with 52 minutes played, was Villarreal's first goal in five league games but it was not enough to give them their first La Liga away win of the year.
In a scrappy game Getafe deservedly drew level with a fine header from Castro after 64 minutes and Pedro Leon had the chance to win the game but his shot following a breakaway was parried by Villarreal keeper Sergio Asenjo.
Villarreal have failed to win in seven games in all competitions and are sixth on 51 points.
Getafe are 13th on 36 points.
"We looked strong after going ahead but then Getafe scored during their best spell. After that we once again looked strong but the injury to Mateo made it more difficult for us as we were left with 10," added Marcelino.
An 18-match unbeaten run up until February saw Villarreal alive on three fronts but in the last couple of months the wheels have come off.
They were knocked out of the King's Cup and the Europa League while their dreams of a Champions League spot have faded.
Elsewhere, Sergio Garcia gave Espanyol a 1-0 home victory over Athletic Bilbao that moved them up to eighth and Real Sociedad could only draw 2-2 at home with struggling Deportivo la Coruna.
Sociedad twice went ahead but the Galician side fought back with goals from Lucas Perez and Toche.
Enzo Roco and Mario Pasalic scored as Elche won 2-0 at bottom side Cordoba.
Image: Ikechukwu Uche scored off a penalty for Villarreal to draw first blood.
Photograph: Manuel Queimadelos Alonso/Getty Images
