FA Cup holders Arsenal were stunned 4-2 by second-tier Nottingham Forest in the third round on Sunday.
Eric Lichaj scored twice for the hosts either side of a Per Mertesacker equaliser to give Forest a 2-1 halftime lead.
Ben Brereton, one of seven players aged 23 or under in the Forest side, made it 3-1 from the penalty spot in the 64th minute.
Danny Welbeck took advantage of an error to pull a goal back for Arsenal with 12 minutes left but Forest were awarded another penalty which Kieran Dowell converted.
It is the first time Arsenal have lost in the third round since 1996 and the first time since Arsene Wenger took over.
Harry Kane took his goal tally for the season in all competitions to 27 with a quickfire double in Tottenham Hotspur's 3-0 victory over third-tier AFC Wimbledon in the FA Cup third round at Wembley Stadium.
Premier League Tottenham were labouring to break down the visitors before Kane effectively sealed the tie with goals in the 64th and 66th minutes. Jan Vertonghen added his side's third.
Wimbledon had proved stubborn opposition until a Moussa Sissoko cross found Kane who slid in to prod the ball home.
Kane made it 2-0 when he turned in an attempted shot by team mate Kyle Walker-Peters from close range.
Vertonghen fired home a spectacular third goal from distance eight minutes later for his first Tottenham goal for four years.
AFC Wimbledon, founded in 2002 to replace the existing club that became Milton Keynes Dons and who have worked their way back up through the various leagues, came close to scoring in the first half when Jimmy Abdou's shot hit the bar.
Newport County provided the weekend's second sizeable FA Cup shock as the Welsh club knocked out former winners Leeds United in the third round with a last-gasp 2-1 victory.
The fourth-tier outfit bridged a 53-place gap in the standings as substitute Shawn McCoulsky, the day after his 21st birthday, condemned the Championship side to a humbling defeat with a powerful 89th-minute header.
Top flight West Ham United also flirted with danger at League One (third-tier) high-flyers Shrewsbury Town on Sunday, escaping with a 0-0 draw after being largely outplayed.
Eight-times winners Tottenham Hotspur were in action at home against third-tier AFC Wimbledon and holders Arsenal were at Nottingham Forest later on Sunday.
For old-fashioned Cup magic the place to be was Rodney Parade in south Wales where Newport became the latest underdogs to embarrass once mighty Leeds -- sparking a joyful pitch invasion by the home faithful.
Gaetano Berardi's deflected ninth-minute strike had looked like winning the tie for Leeds, who were knocked out by minor league Sutton United last season, but Conor Shaughnessy's own goal 15 minutes from fulltime set up a thrilling climax.
McCoulsky ensured it was one of the best days in modest Newport's history with an unstoppable header.
"I can't remember most of it, it was a blur to be honest. It is definitely one of my best goals, to knock Leeds out of the FA Cup is what dreams are made of," he said.
It is not the first time Leeds have suffered a Cup shock across the other side of the Severn Bridge -- having fallen to Cardiff, also 53 places lower than them when they were a Premier League side, in 2002.
To complete a dismal day for Leeds they had substitute Samuel Saiz sent off in stoppage time.