The match was reduced to nine overs per side and South Africa were led by a spectacular 47 not out from Hashim Amla [ Images ] as they notched up 77 for five wickets.
Steven Finn took two for 17 from his two overs as the batsmen and fielding side struggled in the greasy conditions, Jacques Kallis [ Images ] (13 not out) helping to boost the score at the end with a seven-ball cameo.
The rain showed no sign of abating as England's batsmen took the field and they never got going, opener Craig Kieswetter swiping desperately at Morne Morkel's [ Images ] first over.
England were 29 for two off 4.1 overs when the umpires, aware that five balls were required to force a result under the Duckworth-Lewis method, called the players off the field.
South Africa won the first match on Saturday and can seal a series victory in the third game on Wednesday ahead of the Sept. 18-Oct. 7 Twenty20 World Cup in Sri Lanka [ Images ].