Jose Mourinho maintained his hold over Arsene Wenger with leaders Chelsea enjoying a routine 2-0 win over Arsenal on Sunday after the two old adversaries became involved in an ugly touchline spat.
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It will have made uneasy viewing for coach Jorge Sampaoli and emphasised more than ever how reliant his side are on their talisman Messi, who has been struggling with a muscle problem.
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Switzerland struck twice in quick succession to stun Euro 2016 champions Portugal 2-0 in a World Cup qualifier on Tuesday and hand them a first competitive defeat in two years under coach Fernando Santos.