City are 18 points clear of second-placed Liverpool after beating Chelsea 1-0 at the Etihad Stadium on Sunday and need just four wins from their final nine games to be sure of the title.
Former England and Manchester United defender Rio Ferdinand announced his retirement from football on Saturday after being released by Queens Park Rangers.
You would have been hard pressed at the start of the season to find anyone to bet on Liverpool's Brendan Rodgers becoming the first Premier League manager to get the sack, but he is now the bookies' joint favourite.
Arsenal travel across town to a vengeful Chelsea on Saturday knowing that another depressing defeat at Stamford Bridge would see their Premier League title hopes swept away with the lunchtime leftovers.
Liverpool scored a stunning 3-2 win over bottom side Queens Park Rangers with four goals coming in a frenzied seven-minute finale at Loftus Road as the drama continued in the Premier League on Sunday.
England soccer coach Roy Hodgson's four-year reign came to an abrupt end after their shock 2-1 defeat by tiny Iceland at the Euro 2016 round of 16 stage on Monday.
For Manchester United, the answer to a slump in form or a crisis of confidence comes in 50 pound notes. Millions of them.
Bernardo Silva has made an encouraging start to the Premier League campaign and the Manchester City midfielder said that feeling more settled at his second season with the champions was a key factor in his performances.
Tottenham Hotspur head coach Tim Sherwood is looking to the example set by Brendan Rodgers' resurgent Liverpool as he plots for the future despite not receiving long-term assurances about his own position.
Tottenham Hotspur have given the inexperienced Tim Sherwood the chance to stamp his mark on the ambitious London club by naming him on Monday as head coach until the end of next season with their sights on the top four.
Manchester United are likely to welcome back captain Wayne Rooney from suspension for their visit to Premier League champions Manchester City on Sunday, hoping the striker can add to his record scoring tally in the derby.