Manchester United and Manchester City could both get knocked out of the Champions League on Wednesday while French champions Lille will also endure a nerve-wracking 90 minutes.
Manchester United return to the scene of their recent domestic humiliation for Wednesday's Champions League game at home to Otelul Galati without captain Nemanja Vidic who has been the tonic easing their recovery.
Manchester's two-pronged assault on the Champions League finally sprang to life on Tuesday when United won their first match of the campaign by beating Romanians Otelul Galati 2-0 away and City left it until stoppage time to beat Villarreal 2-1.
Real Madrid host Olympique Lyon aiming to continue their perfect start in the Champions League on Tuesday but some of the other heavyweights are still playing catch-up.
Manchester United striker has refused to come out of international retirement after several hundred Bulgarian fans made the trip to Romania to urge him to change his mind.
Images from the UEFA Champions League matches played across Europe on Tuesday.
Manchester rivals City and United have so far not taken their domestic form into Europe and will be among 15 teams attempting to win their first matches in the Champions League group stage this week.
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