Edin Dzeko's first-half header lifted Manchester City three points clear at the top of the Premier League as the leaders swapped flair for functionality in a gritty 1-0 win at bottom club Wigan Athletic.
Bayern Munich needed a stoppage-time winner from Bastian Schweinsteiger to beat VfL Wolfsburg 2-1 and successfully kick off their Bundesliga title defence on Friday.
Manchester City humbled their neighbours United by beating them 6-1 and Levante still lead in Spain where European champions Barcelona were held to a 0-0 draw by Sevilla.
Manchester City crushed Manchester United 6-1 for their biggest win at Old Trafford for 56 years to go five points clear of the champions at the top of the Premier League on Sunday.
Manchester United and Manchester City left their tortured opponents and the Premier League in no doubt they are the teams to beat this season after hugely confident demolitions of Arsenal and Tottenham Hotspur on Sunday.
Manchester City's new striker Sergio Aguero netted twice on a spectacular debut after coming off the bench in their 4-0 home win over promoted Swansea City on Monday as the potential Premier League title challengers made an impressive start.
Atletico celebrate anniversary with 3-1 comeback win over Mallorca
A sparkling two-goal display by Carlos Tevez overshadowed a promising debut by Edin Dzeko as Manchester City claimed a nervy 4-3 win over Wolverhampton Wanderers to go top of the Premier League on Saturday. Dzeko, a 27 million pounds ($42.77 million) buy from VfL Wolfsburg, made a good first impression as City led 4-1 but they were hanging on at the end against the doughty visitors.
New signing Edin Dzeko made his debut but it was partner Carlos Tevez who scored twice in a nervy 4-3 home win over Wolverhampton Wanderers that took Manchester City top of the Premier League on Saturday.
Images from the UEFA Champions League matches played on Tuesday.
Here is a round-up of results from the European League matches played on Friday.
VfL Wolfsburg striker Grafite is optimistic the German side have the team spirit to end Manchester United's impressive Champions League home record when the sides meet in Group B on Wednesday.
Werder Bremen battled back with a stoppage-time goal from defender Per Mertesacker to draw 2-2 with champions VfL Wolfsburg on Saturday and go top of the Bundesliga table on goal difference.
Champions VfL Wolfsburg surged back from a goal down to beat Cologne 3-1 on Saturday to stay top of the Bundesliga after two matches.
Bosnian striker Edin Dzeko scored a hat-trick as leaders VfL Wolfsburg crushed Hanover 96 5-0 away on Saturday to close in on their first Bundesliga title with one match left. The league's leading striker Grafite added two more for Wolfsburg, who are top with 66 points, two ahead of Bayern Munich who were held to a 2-2 draw at Hoffenheim.
Chelsea's commanding start to the Premier League season continued with a 3-0 victory over Aston Villa on Saturday as their rivals for the title continued to look vulnerable.
Shell-shocked AS Roma followed up their midweek Champions League debacle in Barcelona by losing 2-0 at home to nine-man Atalanta in Serie A on Sunday.
Bosnia beat Iran 3-1 in their Group F finale on Wednesday to record their first World Cup win and deny the West Asians any chance of reaching the knockout stage.
Defending champions Manchester City scintillated a stellar performance to record an emphatic 5-0 win over Newcastle, and reduced Chelsea's advantage to five points in the Premier League table on Saturday at Etihad Stadium.
"If they don't get VAR in the Champions League, it is an absolute joke."
Manchester City have bolstered their attacking arsenal with the signing of Ivory Coast forward Wilfried Bony from Swansea City, the English champions said on Wednesday.
Francesco Totti, two days short of his 40th birthday, scored his 250th Serie A goal for AS Roma on Sunday but it was not enough as they lost 3-1 at Torino.
Edin Dzeko scored twice to set up a 3-1 win for AS Roma away to Napoli in the battle for second place in Serie A on Saturday and Paulo Dybala also notched up a brace for leaders Juventus in their 2-1 win over Udinese.
Manchester City striker Sergio Aguero has been ruled out for a month with a calf injury sustained in Saturday's 6-3 win over Arsenal, manager Manuel Pellegrini said on Monday.
Lazio, having endured a miserable start to the season, had high hopes of victory at Genoa, who were languishing in the relegation zone at the start of the day.
Bosnia captain Edin Dzeko struck a hat-trick to kick-start their Euro 2016 qualifying campaign as they beat no-hopers Andorra 3-0 in a one-sided Group B match in Andorra La Vella on Saturday.
AS Roma pulled off one of the great Champions League comebacks by knocking Barcelona out with a remarkable 3-0 win in their quarter-final second leg on Tuesday, overcoming a 4-1 deficit from the first game to reach the last four on away goals.
IMAGES from the Champions League matches played on Tuesday
After losing only three league games last season Juventus have now lost the first two of the new campaign as a deserved 2-1 defeat at AS Roma on Sunday condemned the champions to their worst-ever Serie A start.
Manchester City's hopes of an unprecedented quadruple were in tatters on Sunday after holders Wigan Athletic repeated their FA Cup heroics with a stunning 2-1 victory in their quarter-final at the Etihad Stadium.
Carlo Ancelotti's side held a two-goal lead at halftime thanks to strikes from Dries Mertens and Kostas Manolas, but Balotelli pulled one back as Brescia rallied after the break.
Manchester City conceded four goals in 36 hapless minutes on Saturday as they slumped to a 4-2 defeat by VfB Stuttgart in a pre-season friendly.
A round-up of Tuesday's action in the UEFA Champions League.
A round-up of Wednesday's action in the UEFA Champions League.
A round-up of matches played in the Serie A and French Ligue 1 on Sunday
Frank Lampard and Edin Dzeko scored twice as holders Manchester City sailed into the English League Cup fourth round with a crushing 7-0 win over Sheffield Wednesday and Chelsea beat Bolton Wanderers 2-1 on Wednesday.
Bayern Munich defender Jerome Boateng returned to haunt his former club with a last-gasp goal that secured a 1-0 win over English title holders Manchester City in their opening Champions League Group E clash on Wednesday.
United's Ibrahimovic, Roma's Dzeko find the net thrice to give clubs first leg advantage
Manchester City went top of the Premier League after securing a controversial 2-0 win at Newcastle United on Sunday with an early Edin Dzeko goal and a stoppage time effort from Alvaro Negredo.
However, a Serie A recommendation that similar cuts be made at all top flight clubs has been rejected by the players' union which argues that those at smaller clubs are less able to afford reductions.