Former US Open champion Del Potro fired down 11 aces and did not face a break point during the one hour, 33 minutes match.
Venus Williams became one of the oldest players to win a WTA title when she beat Caroline Wozniacki in the final of the Auckland Classic on Saturday.
Britain's Johanna Konta overpowered Agnieszka Radwanska 6-4, 6-2 in a one-sided victory in the final of the Sydney International on Friday to claim her second career WTA title.
Top seed Dominic Thiem was knocked out the Rio Open in the first round on Tuesday, going down 6-3, 6-3 to Laslo Djere.
Photos from Day 1 of the Australian Open matches played at Melbourne Park on Monday
Garbine Muguruza's preparations for next week's Australian Open were thrown into disarray when the world number three pulled out of the Sydney International with a thigh injury on Wednesday.
Nick Kyrgios clinched his maiden tour title on home soil in a big confidence boost ahead of the Australian Open, beating Ryan Harrison 6-4, 6-2 in the Brisbane International final.
Former world number one Andy Murray withdrew from the Brisbane International with a hip problem on Tuesday, further putting in doubt the Briton's prospects of being fit in time for the Australian Open later this month.
The Danish World No 3 ended 2017 with the biggest title of her career in Singapore and returned a day after thrashing Madison Brengle in her season opener to hit 21 winners against eight unforced errors in the 53-minute win over Martic.
As the players warm up before the tournament, meet the players who could well be contenders for the 2017 Australian Open titles.
Images from Day 1 of the Australian Open, in Melbourne, on Monday.
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