Sergio Aguero scored five times in 20 minutes including an eight-minute hat-trick as Manchester City came from behind to thrash Newcastle United 6-1 and go back to the top of the Premier League table on Saturday.
Manchester City maintained their perfect start to the season with a 2-0 victory over promoted Watford as champions Chelsea suffered a shock 2-1 home defeat by Crystal Palace on Saturday.
Manchester United eased the pressure on manager Ole Gunnar Solskjaer with a 3-1 win at Everton in the Premier League on Saturday with Bruno Fernandes scoring twice and Edinson Cavani grabbing his first for the club.
A round-up of Saturday's Euro 2020 qualifying matches.
Despite a splurge of summer spending of more than 500 million pounds and counting, it was a free transfer from France who provided one of the standout moments of the Premier League's big kickoff.
Chelsea manager Maurizio Sarri made a winning start to life in the Premier League as his team enjoyed a 3-0 win over Huddersfield Town at the John Smith's Stadium on Saturday.
Manchester United maintained their push for a Champions League place after a Juan Mata goal on Saturday pushed Norwich City to the brink of relegation.
Match-by-match facts and statistics ahead of round 11 of the Premier League on Nov. 3-5:
Images from the EPL matches played on Saturday
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
Two brilliant strikes from Isco and a late goal from Alvaro Morata gave Spain a spectacular 3-0 win over Italy, their nearest challengers in Group G, to move into the driving seat for automatic qualification to the 2018 World Cup.
Premier League leaders Manchester City turned on the style with a 3-1 win over Manchester United in their derby clash, on Sunday, leaving Pep Guardiola's unbeaten side two points clear of Liverpool.
Tottenham Hotspur fluffed their last-day lines with a 5-1 defeat at relegated, 10-man Newcastle United that left them third in the Premier League behind bitter north London rivals Arsenal.
Liverpool beat Leicester City 2-1 to post a fourth successive Premier League victory but conceded their first goal of the season after a nightmare mistake by new keeper Alisson.
News of all that's transpired on and off the football field
IMAGES from the Euro 2020 qualifiers
Ole Gunnar Solskjaer continued his dream start as Manchester United caretaker manager with a 3-1 Premier League win over Huddersfield on his Old Trafford debut in the dugout on Wednesday.
IMAGES from the 2020 Euro Qualifiers played on Monday
News of all that's transpired on and off the football field
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another to keep the Catalans five points clear at the top of La Liga.
Spain started their World Cup qualifying campaign with a crushing 8-0 win over Liechtenstein, laying down a marker in Group G with a ruthless second-half display on Monday.
Karim Benzema came off the bench to score 13 minutes from time and ruin any chance of a dream result for resilient Ludogorets as holders Real Madrid carved out a patchy 2-1 win in Wednesday's Champions League Group B match.
Schuerrle hits treble for the world champs; Lewandowski helps Poland thrash Georgia
It will have made uneasy viewing for coach Jorge Sampaoli and emphasised more than ever how reliant his side are on their talisman Messi, who has been struggling with a muscle problem.