Frenchman Adrian Mannarino also quit at two sets apiece against eight-times champion Roger Federer after sliding over on Centre Court and injuring his knee.
The second round match between former champion Angelique Kerber and Anhelina Kalinina, originally scheduled to begin after Schwartzman and Anderson, was pushed to Thursday.
Belarusian ninth seed Aryna Sabalenka held off a spirited challenge from American Alison Riske to win 6-3, 3-6, 6-1 and successfully defend her Wuhan Open title on Saturday.
Mercifully the set flashed by in 16 breathtaking minutes as Federer whizzed into the quarter-finals with a 6-0, 7-5, 6-4 win.
A summary of Wednesday's action at the US Open.
He made a solid start against France's Adrian Mannarino to take a 5-2 lead in the opening set but injured his wrist in the eighth game before retiring.
IMAGES from Day 5 of the 2020 US Open in New York on Friday.
World number one Novak Djokovic had to work hard for a three-set victory over Hungarian Marton Fucsovics at the Paris Masters on Tuesday in his first match since losing the U.S. Open final in September.
Kristina Mladenovic had complained saying she felt like she was being treated like a prisoner after she was placed inside a 'bubble within a bubble' despite 'thirty negative tests'.
France, who were 2-0 up courtesy of Arthur Rinderknech and Adrian Mannarino, faced little resistance from Ecuador as wins for Benjamin Bonzi and the doubles pair of Pierre-Hugues Herbert and Nicholas Mahut secured victory for the 10-times champions.
Norrie's semi-final opponent will be another American, fourth-seeded Tommy Paul, who crushed Stefan Kozlov 6-3, 6-1 in an all-US matchup.
As Roger Federer chases a 21st Grand Slam title, it looks like he knows his cricket shots too.
Feliciano Lopez has denied any involvement in match-fixing after his name was mentioned in a media report concerning a doubles match with fellow Spaniard Marc Lopez.
Alexander Zverev suffered a surprise defeat against Frenchman Ugo Humbert
France's Benoit Paire has tested positive for COVID-19 and pulled out of the US Open starting on Monday, French sports daily reported on Sunday. Paire, seeded 17th at the Grand Slam event, had been scheduled to play Poland's Kamil Majchrzak in the first round at Flushing Meadows on Tuesday.
Andy Murray launched a fresh rocket at his US Open conqueror Stefanos Tsitsipas on Tuesday, griping that the Greek player took longer on bathroom breaks than it took billionaire Jeff Bezos to reach outer space.
The Serbian second seed's match against France's Adrian Mannarino was delayed because of the epic five-setter between Gilles Muller and Rafael Nadal.
Eight-time Wimbledon champion Roger Federer, who turns 40 this year, takes on Frenchman Adrian Mannarino in round one.
Tsonga outplayed his compatriot Adrian Mannarino 6-2, 6-2 in the opening round of the traditional Wimbledon warm-up event in his first match since suffering a four-set defeat by little-known Argentine Renzo Olivo at Roland Garros.
Favourites Russia Tennis Federation opened their Davis Cup Finals campaign with a resounding victory over Ecuador, Britain began with a win against France and Italy eased into the quarter-finals with a win over Colombia on Saturday.
Federer showed that he is prepared to take as many knocks as it takes to keep alive his dreams
Tennis great Serena Williams limped out of Wimbledon in tears on Tuesday after her latest bid for a record-equalling 24th Grand Slam singles crown ended in injury.
Despite being the king of Wimbledon, Federer has found himself in the same strict bubble as every other player in the draw this year, rather than in his usual plush rented house with his family a stroll away from the grounds.
Nadal becomes just the fourth man to achieve 1,000 singles victories in the Open Era, behind Jimmy Connors (1,274), Roger Federer (1,242) and Ivan Lendl (1,068).
A summary of sports events and sports persons who made news on Sunday.
Second seed Novak Djokovic complained of a "hole" on Centre Court at Wimbledon after beating Adrian Mannarino in his delayed fourth-round match on Tuesday.
Spaniard Feliciano Lopez showed a compassionate streak in addition to a dangerous serve by apologising to the ball-boy he struck in the groin at the Australian Open.
Second seed Rafael Nadal survived a late fightback from Adrian Mannarino as he beat the French qualifier 6-1, 7-6(6) on Thursday to reach the quarter-finals of the China Open during a rain-hit day in Beijing.
Top seed Rafa Nadal, who has won the tournament 10 times, also reached the last eight after dispatching compatriot Guillermo Garcia-Lopez 6-1, 6-3 and claiming a record-extending 40th consecutive set on clay.
Novak Djokovic chalked up his 800th career victory to reach the semi-finals of the Fever-Tree Queen's Club championships on Friday and suggested he could play on past his 40th birthday.
'I definitely feel like I've got my rhythm now at this point. Clearly I've gone from lefty to righty to lefty.'
Roger Federer celebrated his return to the top of the world rankings with his second title of the season, swatting aside Grigor Dimitrov 6-2, 6-2 in the final of the ABN AMRO World Tournament in Rotterdam on Sunday.
Federer, Djokovic headline Day 2 at Flushing Meadows
Images from Day 5 of the 2021 US Open in New York on Friday.
Roger Federer's late bid to secure his customary place in the season-ending ATP World Tour finals began with a routine opening round win over Adrian Mannarino in his home town tournament in Basel on Monday.
World No 2 Rafael Nadal brushed aside American Jared Donaldson 6-1, 6-1 and will next face Diego Schwartzman after the Argentine beat Roberto Carballes 6-3, 6-1.
Roger Federer and Rafael Nadal advanced to the quarter-finals of the BNP Paribas Open.
Images from Day 4 of the Wimbledon tennis championships played in London, on Wednesday.
Novak Djokovic brushed past France's Adrian Mannarino 6-4 6-3 7-6(5) on Wednesday to book his place in the third round of Wimbledon. The defending champion, aiming for his third consecutive title, played well within himself and was rarely troubled during the second-round match. Mannarino, ranked 55, put up spirited resistance in the third set to force a tiebreak but was ultimately swept off Centre Court by the Serbian's laser-guided ground-strokes.
Three-time Wimbledon champion Novak Djokovic roared his way into the fourth round with a 6-4, 6-1, 7-6(2) defeat of unpredictable Latvian Ernests Gulbis on Centre Court.