Sevilla became surprise Liga leaders on Sunday after beating visiting Celta Viga 2-1 while champions Barcelona drew 1-1 at Valencia thanks to another Lionel Messi strike but are still without a victory in their last four league games.
The Italian coach considers that having healthy players, such as striker Karim Benzema, will be the key to face the schedule that awaits the Madrid side, who will be looking to defend their LaLiga, Spanish Super Cup and Champions League titles.
Barcelona and Real Madrid both drew away against sides battling relegation in La Liga on Saturday as the top two focused their attentions on next week's Champions League quarter-finals.
Real Madrid extended their unbeaten run to 25 matches and rejoined Barcelona and Atletico Madrid at the top of La Liga when Jese, Karim Benzema and Luka Modric scored in a 3-0 win at Getafe on Sunday.
Barcelona forward Ousmane Dembele scored twice and produced a mesmerising display to fire his side to a 5-1 win over Villarreal on Wednesday which stretched the champions' unbeaten run this season to 36 games with two remaining.
Atletico Madrid have been unable to repeat the magnificent achievements of last season in this campaign but can congratulate themselves on a job well done if they secure a lucrative Champions League berth on Saturday.
Real Madrid followed up Tuesday's Champions League success at Manchester United by climbing above beaten city rivals Atletico into second in La Liga when Cristiano Ronaldo struck twice in a 2-1 win at second-bottom Celta Vigo on Sunday.
Reaching the King's Cup final is of even greater importance than usual for Real Madrid following a demoralising setback in La Liga.
Lionel Messi netted the 400th goal of his storied career on Saturday as Barcelona trounced Granada 6-0 to maintain the pace at the top of La Liga.
Real Madrid's early-season woes deepened when they lost 2-1 at home to La Liga champions Atletico Madrid, while substitute Neymar struck twice in Barcelona's 2-0 win against visiting Athletic Bilbao on Saturday.
Real Madrid forward Cristiano Ronaldo aggravated a leg muscle injury in Saturday's 2-1 win over city rivals Atletico, the La Liga club said.
Former Barcelona defender Alba to sign for Inter Miami
Lionel Messi scored in his 12th consecutive La Liga game to help leaders Barcelona earn a 1-1 draw at Valencia, allowing second-placed Atletico Madrid to close to within nine points after a 1-0 win over Real Betis on Sunday.
Gundogan was Pep Guardiola's first recruit when he took over the reins at City in 2016 despite the German being sidelined with a knee injury when he was signed from Borussia Dortmund.
City completed the treble of Champions League, Premier League and FA Cup titles, matching Manchester United's feat in 1999 and drawing comparisons with Guardiola's 2008-09 Barcelona team.
Real Madrid brushed off the absence of Cristiano Ronaldo and Gareth Bale to beat Espanyol 2-0 away and maintain their 100 per cent start to the league season while matching the La Liga record of 16 consecutive victories.
Real Madrid strikers Karim Benzema and Gonzalo Higuain are doubts for the trip to play Levante in La Liga on Sunday, a ground that has proved an uncomfortable venue for Jose Mourinho's side over the last two seasons.
Real Madrid moved closer to retaining their Primera Liga title with a 2-0 win away at Racing Santander.
A red hot Luis Suarez scored four goals and contributed three assists as Barcelona's stuttering La Liga title charge sparked back to life with a spectacular 8-0 thrashing of Deportivo La Coruna on Wednesday.
Photos from the La Liga matches played on Sunday
Leaders Barcelona kept up their relentless pace at the top of La Liga with a 4-0 thrashing of city rivals Espanyol and 10-man Real Madrid needed two goals from Cristiano Ronaldo to see off Real Sociedad 4-3 on Sunday.
Real Madrid's La Liga title hopes suffered a huge blow with a surprise 1-0 defeat at Osasuna on Sunday which left Jose Mourinho's side seven points adrift of leaders Barcelona.
Lionel Messi scored two late goals on Saturday as leaders Barcelona won 3-0 away to Hercules, their 15th consecutive victory matching the La Liga record set by Real Madrid in the 1960-61 season.
Cani's brilliant effort from just inside Osasuna's half helped Villarreal to a 4-2 home win as La Liga reached the midway point of the season on Saturday.
Atletico Madrid cruised to a 3-0 home win over Real Sociedad on Tuesday to close the gap behind La Liga leaders Barcelona to five points.
A Cristiano Ronaldo hat-trick helped Real Madrid fight back to beat classy Villarreal 4-2 on Sunday to cut Barcelona's La Liga lead to two points.
Lionel Messi hit a hat-trick as Barcelona warmed up for the El Clasico with Real Madrid next weekend with a 7-0 victory over Osasuna that put them four points off the top of La Liga.
Midfielder Dani Ceballos added: "It looks like us changing our coach worked. We have recovered some sensations we had lost and we have got the three points. Now our objective is to win all the games left and finish the season as well as possible."
Newly-crowned champions Real Madrid beat Mallorca 4-1 to break the 100-point barrier on the final day of La Liga season as Villarreal sensationally slipped through the relegation trapdoor.
Valencia's Paco Alcacer and Dani Parejo both hit doubles in a surprise 5-1 away thrashing of high-flying Celta Vigo in La Liga on Saturday.
A lacklustre Barcelona squandered the chance to go top of La Liga after crashing to a shock 1-0 home defeat by Malaga on Saturday.
Sevilla and Valencia recorded opening day wins in La Liga, helping dispel some of the doubts surrounding their abilities to challenge for honours this season.
Barcelona equalled the La Liga record for the most points after 10 games and moved three clear of Atletico Madrid at the top of the table thanks to a 3-1 win at home to Celta Vigo on Saturday.
Barcelona's Lionel Messi, Luis Suarez and Neymar motored past 100 goals for the season.
Atletico Madrid moved a step closer to an unlikely Spanish title triumph when they battled back from a goal down to secure a 2-1 win at fourth-placed Athletic Bilbao in La Liga on Saturday.
James Rodriguez headed the opener before going off injured in Real Madrid's win.
David Moyes' honeymoon as coach of Real Sociedad came to an abrupt end when they were trounced 4-0 by Villarreal.
Barca's second-half stamina key to their massive lead in the standings this season
Real Madrid romped to a 4-1 win at tiny Eibar on Saturday, provisionally returning to the top of La Liga, despite the absence of Gareth Bale and Cristiano Ronaldo for Zinedine Zidane's side.
Paris St Germain closed out the year on a high as they maintained their five-point advantage at the top of the table.