Real play Athletic Bilbao while Barcelona visit Real Sociedad in fixtures that have often proved to be among their hardest away trips over the last decade.
Thierry Henry scored a hat-trick as Barcelona crushed Valencia 4-0 at the Nou Camp to move six points clear at the top of the Primera Liga on Saturday.
Arsenal suffered a shock Europa League exit to Olympiakos Piraeus on away goals after a 2-1 extra-time home defeat, while Manchester United and Wolverhampton Wanderers cruised into the last 16 with emphatic aggregate wins on Thursday.
A signed pair of Lionel Messi's boots have been sold for 4,000 euros (2,700 pounds) at an auction in Beijing on Barcelona's tour of Asia, Spanish media reported on Sunday.
A round-up of Friday's action in La Liga, and Bundesliga.
Substitute Toni Kroos hit a last-gasp winner as four-times European champions Bayern Munich came from behind to win 3-2 at Red Star Belgrade in the UEFA Cup.
The Premier League club did not say who would replace Jol, although Seville's Juande Ramos is expected to take over.
Barcelona forward Ousmane Dembele scored twice and produced a mesmerising display to fire his side to a 5-1 win over Villarreal on Wednesday which stretched the champions' unbeaten run this season to 36 games with two remaining.
Injury could affect Beckham's move to Major League Soccer in America.
Joining them in the last four were Getafe and Deportivo Coruna.
After an even first 45 minutes, strikes from Pablo Sarabia and Wissam Ben Yedder stunned the Catalans and left them needing a second-leg comeback at the Nou Camp for the second consecutive round in the competition.
Manchester United, Sevilla and Celtic led a parade of clubs with continental pedigree to book the first places in this season's Europa League knockout stage.
Leaders Real Madrid edged closer to the Primera Liga title beating Deportivo Coruna 3-1 in the Bernabeu on Saturday.
Barcelona captain Lionel Messi scored two goals and set up two more as the Catalans thrashed Real Valladolid 5-1 to move top of La Liga on Tuesday.
Fabio Capello's Real Madrid suffered a double blow on Saturday when they slumped to their first league defeat of the season, 1-0 away to Getafe, and had striker Ronaldo sent off in the dying minutes.
Alexis Sanchez hit a hat-trick as Barcelona swept aside Elche 4-0 to return to the top of La Liga on goal difference ahead of Atletico Madrid on Sunday.
Images from Sunday's action in La Liga, Serie A and Ligue 1.
La Liga leaders Barcelona beat Real Madrid 1-0 to all but knock their rivals out of the title race on Saturday, while second-placed Atletico Madrid stayed seven points behind the Catalans with a 2-0 win at Real Sociedad on Sunday.
Martial scored his 23rd goal for United in all competitions this season against LASK Linz in Wednesday's Europa League last-16 victory.
On a good night for English clubs in the Europa League, Manchester United hammered AZ Alkmaar 4-0, while Wolverhampton Wanderers also thrashed Besiktas 4-0 in Group K, and Arsenal came from two goals down to draw 2-2 away to Standard Liege and finish first in their pool. The upset of the night came in Group J as Crivelli scored a 90th-minute winner against Borussia Moenchengladbach to send Basaksehir through and knock the Germans out, with AS Roma grabbing the runner-up spot thanks to a 2-2 home draw with Wolfsberger as the Europa League group stage concluded on Thursday.
A round-up of weekend action in the main European leagues.
Lionel Messi may lack a World Cup for Argentina but his 10 years with Barcelona have seen him rewrite the history books and become symbolic with the club's golden era.
A 3-0 victory took Barcelona to the top of the Primera Liga.
Barcelona surrendered lead to arch-rivals Real Madrid after they were held to a 1-1 draw at home to Real Betis.
Real Madrid drew 1-1 at home with local rivals Getafe in the Bernabeu.
The 53-year-old Brazilian, who was Real's fifth coach in the space of two and a half years, was dismissed following an emergency board meeting at the club's Bernabeu stadium.
A round-up of weekend action in the major European leagues.
Sevilla knocked Barcelona off the top of the Primera Liga after goals from Frederic Kanoute and Adriano Correia earned a 2-0 home win over Osasuna on Sunday.
Barcelona are on the verge of completing a reported 30 million euro ($33.57 million) move for Spain international Paco Alcacer from Valencia after the striker arrived for a medical with the La Liga champions on Monday.
Manchester City must rebuild for title challenge: Guardiola
Real Betis came from a goal down to earn a 3-2 win at home to Real Zaragoza and stay in the hunt for a spot in the elite league.
Barca are top on 72 points, Real have 66 and Sevilla, who lost 1-0 at home to Osasuna on Saturday, are a distant third on 52.
Espanyol secured a commanding lead in their King's Cup quarter-final tie against Sevilla when Felipe Caicedo, Sergio Garcia, with a penalty, and Lucas Vazquez scored in a 3-1 first-leg home win on Thursday.
La Liga leaders Barcelona earned a narrow 1-0 win over Real Valladolid to move seven points clear at the top, while Real Madrid lost 2-1 at home against Girona to fall to third behind Atletico Madrid.
Real Madrid closed to within three points of La Liga leaders Barcelona and Atletico Madrid at the halfway stage of the season when a Pepe header secured a laboured 1-0 win at mid-table Espanyol on Sunday.
Barcelona closed in on the La Liga title by thrashing local rivals Espanyol 5-0 on Sunday as Atletico Madrid dropped out of the race after losing 2-1 at Levante and Real Madrid beat Valencia 3-2.
