United beat Leicester City at Old Trafford in the opening game of the season but Spurs present a very different quality of opponent.
Chelsea's Damien Duff says there is an 80 percent chance he could suffer a recurrence of the dislocated shoulder.
Coach Zico named seven European-based players for matches against Uruguay and the US.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
Manchester United manager Ole Gunnar Solskjaer is eager to build his team around midfielder Paul Pogba despite media speculation linking the French World Cup winner with a move away from Old Trafford.
English champions Manchester United are suddenly in danger of finishing a season empty-handed for the second time in three years.
"We have 11 games to go and we have tricky away games," the Arsenal manager said.
Arsenal beat Fulham 2-0 at the Emirates and Manchester City beat Cardiff City 4-2 at the Etihad before Liverpool could only manage a 2-2 draw at Anfield having trailed 2-0.
Arsenal will reportedly play Chelsea in a fourth-round Capital One Cup match after winning 4-3 on penalties against West Bromwich Albion on Wednesday at The Hawthorns.
The former beat Leeds United 4-1 while Manchester United got the better of Aston Villa 2-1 in the third round of the FA Cup.
The Chelsea winger sustained the injury when he landed heavily after being challenged as he shot at goal.
Liverpool needed two extra-time goals to beat NottsCounty 4-2 at Anfield on an eventful night for the Premier League clubs in the League Cup second round on Tuesday.
A 1-1 draw at Charlton Athletic sent Arsenal back to the top of the premier league.
The Manchester United midfielders have knee injuries and will miss Champions League matches against Basel and Deportivo Coruna.
Champions Manchester United travel to Swansea City for their first Premier League match under new manager David Moyes, while Manuel Pellegrini's Manchester City are at home to Newcastle United on August 17.
Here are five talking points from the weekend's Premier League action:
Ukraine advanced to the Euro 2020 finals after an impressive first half helped them to a 2-1 home win over Portugal, whose talismanic captain Cristiano Ronaldo scored his 700th career goal.
Five talking-points from the Premier League weekend after Manchester United extended their winning run against Tottenham Hotspur, Liverpool were made to work hard for their win at Brighton & Hove Albion and Arsenal losing at West Ham United.
Liverpool opened up a seven-point gap at the top of the English Premier League with a 1-0 win at Brighton & Hove Albion on Saturday, while Arsenal's poor away form continued with a 1-0 defeat at West Ham United.
News of all that's transpired on and off the football field.
Images from the League Cup matches played on Tuesday
Manchester United's 3-0 victory over Fulham gave them the top spot in the English premier league.
Manchester City stumbled to the most unexpected defeat of the Premier League season on Saturday before neighbours Manchester United began their brave new world under Ole Gunnar Solskjaer with a glorious reminder of long-forgotten attacking swagger.
The win allowed second-placed Liverpool to close the gap on league leaders Manchester City to two points.
Stevan Jovetic and Jesus Navas scored their first goals for ManchesterCity who avenged last season's shock FA Cup final defeat by Wigan Athletic with a 5-0 victory in the League Cup third round on Tuesday.
A summary of sports events and sports persons, who made news on Wednesday
Free-scoring Arsenal replaced Chelsea as Premier League leaders as goals either side of halftime by Theo Walcott and Mesut Ozil helped them recover from a slow start to beat Stoke City 3-1 on Saturday.
Chelsea ripped apart Premier League title rivals Arsenal in a 6-0 mauling at Stamford Bridge on Saturday to ensure Arsene Wenger's 1,000th game turned sour and Liverpool and Manchester City kept up the pressure with big wins.
Wales coach Chris Coleman conceded on Thursday that a stoppage-time loss to England was the low point of his career, but he said he could take inspiration from Roy Hodgson's side who had also come back from deep disappointment. Wales led at halftime after a sensational long-range Gareth Bale free kick, but lost 2-1 after Jamie Vardy's equaliser and Daniel Sturridge's winner in the 92nd minute. Asked whether this was the low point of a career that has included spells in charge at Fulham, Real Sociedad and Greek side Larissa in Greece, Coleman responded: "I'd have to say yes to be honest.
Zlatan Ibrahimovic has once again made the shortlist of for FIFA's goal of the year award, giving him a chance to retain the trophy he won last year.
News of all that's transpired on and off the football field
Images from the EPL matches played on Sunday
Eden Hazard scored from the spot in stoppage time to salvage a 2-2 draw for Chelsea against West Bromwich Albion, who were seconds away from inflicting a first Premier League home defeat on a Chelsea side managed by Jose Mourinho.
News of all that's transpired on and off the football field
FC Pune City also bolstered their defence by signing former Espanyol and Deportivo La Coruna defender Diego Colotto for the second edition of the eight-team league beginning on October 3.
Liverpool and champions Manchester City drew 0-0 at Anfield while Chelsea and Arsenal enjoyed comfortable away wins. City are top on goal difference from Liverpool and Chelsea with Arsenal two points behind.
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
Former Manchester United striker Andy Cole is recovering in hospital after undergoing a kidney transplant, the club said in a statement on Friday.
