Zlatan Ibrahimovic's 28th goal of the season in all competitions put United ahead and Sunderland's cause became all but impossible after Seb Larsson was sent off close to halftime.
Premier League champions Leicester City have been warned to behave on their tour to Thailand - after last year's antics led to the sacking of three players and manager Nigel Pearson.
Manchester United stayed put atop the English Premier League after 2-0 victory over Reading as Arsenal routed Fulham 3-0 and Chelsea beat Birmingham City 1-0.
Instead of hoping for a slip-up from Premier League leaders Leicester City, Tottenham Hotspur must win their remaining five games to give Spurs their best chance of winning their first league title since 1961, midfielder Erik Lamela said. The 24-year-old winger has shone under manager Mauricio Pochettino this season, but his four goals and six assists might still not be enough, as second-placed Spurs are still seven points behind Claudio Ranieri's men. "We still believe... Our task is to win all the remaining games. Whether Leicester win or lose, the important thing is that we are concentrated on the job in hand," Lamela told British media. "We have the finish the season in the best manner possible. There are five games left and our aim is five victories." Spurs have the meanest defence in the league, conceding just 25 goals in 33 games, and according to defender Jan Vertonghen that has been crucial in the North London club's impressive run.
Barcelona's Lionel Messi hit his 400th career goal for the La Liga leaders.
Will Meghan Markle's wedding dress match up to these?
Leicester City manager Claudio Ranieri mused on Sunday that, if he had his wish, every one of his wonderful squad would have been honoured as Player of the Year at the Professional Footballers' Association awards night.
Real Madrid forward Cristiano Ronaldo could be sanctioned for his goal celebration when he netted the equaliser in Sunday's La Liga 'Clasico' at Barcelona, the president of Spain's professional football league (LFP) said.
Striker Sergio Aguero has admitted the Premier League title is slipping out of ManchesterCity's reach and urged his teammates to keep rivals Manchester United at bay in the race for Champions League qualification ahead of Sunday's derby.
Tottenham Hotspur's poor start to the season showed little sign of improving when they were beaten 3-1 by Newcastle United.
News of all that's transpired on and off the football field.
Officials from Juventus, Lazio and Fiorentina along with Italy's World Cup referee Massimo De Santis are being investigated.
Leicester City scored two stunning goals in extra time through Wilfred Ndidi and Demarai Gray to reach the FA Cup fifth round with a 3-1 win over second tier Derby County in a replay.
Goals from the prolific duo of Luis Suarez and Neymar earned Barcelona a tight 2-1 win at Las Palmas on Saturday to propel them nine points clear at the top of La Liga.
High drama ensued during the English Premier League matches on Wednesday as Spurs manager Jose Mourinho was booked while Brighton stunned Chelsea via Alireza Jahanbakhsh's superb equaliser to deny the Blues victory. Here is all the EPL action in IMAGES from Wednesday's matches.
The pressure is now on Leicester City's title rivals to remove the Foxes from the top of the Premier League table, manager Claudio Ranieri said after Saturday's thumping 3-1 league victory over Manchester City.
Former Italian Prime Minister Silvio Berlusconi has denied the latest media reports that his AC Milan soccer club was up for sale, saying he was not ready to part with the team he has owned since the 1980s.
Inter Milan captain Javier Zanetti has denied he plans to join Jose Mourinho at Chelsea, despite newspaper reports he could move into coaching at the London club.
Here is a round-up of results from the European League matches played on Wednesday
UEFA Cup holders Sevilla underlined their class with a 2-0 victory over Steau Bucharest.
The former England captain scored on his return to the team after a month on the sidelines to inspire Real Madrid to a 2-1 comeback win at Real Sociedad.
Peru's Claudio Pizarro scored a late equaliser to salvage a 2-2 draw against Bolivia at the Copa America.
Luis Suarez scored a hat-trick, including an exquisite second goal, as Barcelona strolled into the Club World Cup final with a 3-0 win over Asian champions Guangzhou Evergrande on Thursday.
Chelsea are ready to offload flop Juan Veron in a cut-price move to Inter Milan.
Claudio Ranieri delivered an emotional farewell to his stunned Chelsea players on Monday after finally admitting he will be sacked this summer.
Champions Leicester City will begin their Premier League title defence with a trip to newly promoted Hull City on August 13, according to the 2016-17 fixtures released on Wednesday.
The Champions League match lacked intensity, with the German champions already through to the last 16.
The following are talking points from the weekend's Premier League action:
The 21-year old Australian rookie will replace the Spaniard for next season's MotoGP campaign, the team confirmed.
There is no stopping master goalkeeper Gianluigi Buffon in his ambition to add more major titles to his collection of the 2006 World Cup and seven Serie A championships.
Ibrahimovic said he had received offers from the Premier League, Italy and outside Europe but gave no more details.
Five-time world player of the year Lionel Messi of Argentina, Chile's Alexis Sanchez and Brazilian Dani Alves were among the big names in the final rosters announced on Monday for next month's Copa America Centenario.
India will take up with Italy trade-related issues, particularly market access problems faced by Indian exporters, when Commerce Minister Kamal Nath meets his Italian counterpart later this week.
Jamie Vardy continued shooting his way towards a Premier League record when he extended his goal streak in Leicester City's 3-2 victory at West Bromwich Albion on Saturday.
Manchester City coach Pep Guardiola has denied a newspaper report that he tried to sign strikers Lionel Messi and Neymar from former club Barcelona in the close season.
Leicester's Mahrez rules out PSG move
Real Madrid paid homage to Cristiano Ronaldo as their outright leading scorer on Friday even though the official statistics show he has yet to overhaul former Spain striker Raul.
Chelsea midfielder Cesc Fabregas said the uncompromising attitude to hard work of incoming manager Antonio Conte is exactly what is needed to galvanize the outgoing Premier League champions.
Chelsea are now 11 points ahead of Manchester City who have 13 games left to play and while Italian Conte is too cagey to start proclaiming his side yet, only a monumental loss of form can deny them the title.