According to The Hollywood Reporter, the special is titled "Oprah With Meghan and Harry" and it will air on the network on March 7.
The special will also provide viewers the opportunity to peek inside White House.
As the woman who conducted the explosive CBS interview, Winfrey stressed that Harry was categorical that it was neither his grandmother, the Queen, nor his grandfather, who were behind comments about Archie's mixed-race heritage from his mother's side, which are being perceived as racist.
On the couple's reference to unnamed royals raising concerns over their son Archie's mixed-race heritage, the palace said the concerning issues of race would be addressed privately as a family matter.