Ajax, four-times European Cup winners who are in the knockout stages for the first time in 13 years, have enhanced their reputation as a talent factory due to the rise of homegrown Dutch players Frenkie de Jong and Matthijs de Ligt.
Champions Barcelona moved five points clear at the top of La Liga with a 2-1 win at Getafe, while Real Madrid fell to a 2-0 defeat by Real Sociedad.
Lionel Messi dragged a nervous Barcelona to a 1-0 win at home to Levante in La Liga, while Cristiano Ronaldo converted two late penalties on his 100th appearance for Juventus in all competitions as the Serie A titleholders ground out a 3-1 win away to a dogged Genoa side.
Atletico Madrid crashed out of the Copa del Rey to Girona on Wednesday following a highly entertaining 3-3 draw at home to the Catalan side, who sneaked through to the quarter-finals on away goals after the tie finished 4-4 on aggregate.
The 28-year-old is believed to be linked to thwarted attacks on a high-speed train from Amsterdam bound for Paris in August, as well as a planned attack on a Parisian church.
Real Madrid dropped points for the third time in seven games since Zinedine Zidane's return as they were held to a 0-0 draw away to Getafe in La Liga on Thursday, which harmed their neighbours' hopes of a top-four finish.
Karim Benzema netted a second-half hat-trick as Real Madrid got back to winning ways with a 3-0 victory over Athletic Bilbao in La Liga on Sunday.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
Seven arrests made as woman blows herself up and man is killed by grenade during raid on apartment in St-Denis, north of Paris
Images from Champions League matches played across Europe on Tuesday
Five days after deadly attacks in Paris, which claimed 129 lives, details are emerging about the identities of the men who carried out the attacks