The brilliance of Chelsea's Eden Hazard ended Liverpool's 100 percent start to the season as Maurizio Sarri's side enjoyed a 2-1 win at Anfield in the League Cup third round on Wednesday.
Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Such is the impact Sadio Mane has made on Liverpool that the 24-year-old is an automatic pick to face Tottenham Hotspur in the Premier League on Saturday while experienced international teammates scrap it out to play alongside him.
Images from the EPL matches played across England on Saturday.
England coach Roy Hodgson will be strongly tempted to start with Jamie Vardy and Daniel Sturridge in attack against Slovakia on Monday after both came off the bench to score in the 2-1 win over Wales.
Liverpool manager Juergen Klopp is certain his side will improve next season and feels that his first seven months at the Merseyside club have provided a solid foundation for the future.
Daniel Sturridge scored on his Liverpool debut and Luis Suarez caused controversy as the seven-times winners beat minor league Mansfield Town 2-1 to reach the FA Cup fourth round on Sunday.
Liverpool romed into the Europa League final with a 3-0 win over Villarreal on another magical night at Anfield to tee up a showpiece clash with holders Sevilla who swatted away visitors Shakhtar Donetsk 3-1 on Thursday.
Daniel Sturridge headed in the equaliser as Chelsea drew 1-1 with Birmingham City on Saturday to force a replay of their FA Cup fifth-round encounter after a performance that did nothing to alleviate the pressure on manager Andre Villas-Boas.
Roberto Firmino struck a stoppage-time winner as Liverpool beat Paris St Germain 3-2 at Anfield on Tuesday after Kylian Mbappe looked to have secured a point for the French side in a compelling Champions League Group C clash.
Lewis Hamilton saw his net worth rise by 37 million pounds over the last year.
Liverpool's hopes of qualifying for the Champions League all but ended.
Liverpool ran riot to reach the League Cup semi-finals with a 6-1 thrashing of Southampton on Wednesday in which Divock Origi grabbed a hat-trick and Daniel Sturridge scored twice as the Juergen Klopp juggernaut rolled on.
England coach Roy Hodgson, basking in a 2-1 victory over Wales on Thursday clinched by goals from two substitutes, said fringe players would be a major factor at Euro 2016. Gareth Bale put Wales in front before Jamie Vardy and Daniel Sturridge replied, the latter in stoppage time, after both came on in the second half. Hodgson said it was hard to remember if he had made a better double substitution in his 40-year career.
Goals from Adam Lallana and Roberto Firmino put the home side ahead by halftime and they romped to victory with a Giannelli Imbula own goal and Daniel Sturridge strike after Stoke threatened an upset with a Jonathan Walters header.
Manager Brendan Rodgers has ended whatever honeymoon period new striker Mario Balotelli was enjoying at Anfield, telling him he needs to start scoring goals after finding the net just once in seven appearances for Liverpool.
Images from Sunday's Premier League matches.
Liverpool have been told by a tribunal to pay Championship (second-tier) leaders Burnley up to eight million pounds ($11.7 million) for striker Danny Ings.
Liverpool's 1-0 defeat by Aston Villa on Saturday was more than an early season setback - it raised the question of whether they have the strength in depth to cope with the dual challenge ahead of them this term.
Luis Suarez marked his return to Premier League action with two goals to help Liverpool to a 3-1 win at managerless Sunderland that lifted them to second in the table on Sunday.
Liverpool were left frustrated by Championship side Blackburn Rovers who defended heroically to draw 0-0 at Anfield.
Liverpool defender Daniel Agger has been ruled out for up to four weeks with a calf injury, manager Brendan Rodgers said on Friday.
Liverpool's half-baked pre-season transfer dealings have come back to bite them with Brendan Rodgers admitting his side have lacked the quality to finish in the Premier League's top four.
Liverpool's half-baked pre-season transfer dealings have come back to bite them with Brendan Rodgers admitting his side have lacked the quality to finish in the Premier League's top four.
Liverpool handed their fiercest rivals a painful lesson on Thursday with a dominant 2-0 win over Manchester United in the first leg of a Europa League last-16 clash.
The Reds' manager believes his team has the ability to finish in the top four and qualify for Champions League next season.
Members of England's World Cup squad made a flying visit to Brazil's largest shanty-town on Monday, yet observers were left wondering if it achieved little more than 'para ingls ver'.
Liverpool manager Brendan Rodgers says his side must tighten up defensively after a 5-3 victory over Stoke City on Sunday in which Daniel Sturridge resumed his lethal strike partnership with Luis Suarez.
Good news was in short supply for Manchester United manager Jose Mourinho on Saturday as his side were thrashed 4-1 by Liverpool in the International Champions Cup and he confirmed Serbian midfielder Nemanja Matic will miss the start of the season.
Liverpool needed two extra-time goals to beat NottsCounty 4-2 at Anfield on an eventful night for the Premier League clubs in the League Cup second round on Tuesday.
England drew 0-0 with Slovakia on Monday to finish second in Euro 2016 Group B and qualify for the knockout phase behind Wales who beat Russia 3-0 in their final match.
Arsenal captain Mikel Arteta says he has never seen manager Arsene Wenger as angry as he was during the half-time break in Saturday's 5-1 demolition at the hands of Liverpool.
Liverpool manager Brendan Rodgers refused to criticise defender Kolo Toure after his glaring error gifted West Bromwich Albion striker Victor Anichebe an equalising goal in their 1-1 Premier League draw on Sunday.
Arsenal survived a late scare to regain top spot in the Premier League with a 2-1 victory at Aston Villa on Monday, both their goals arriving in the space of a minute in the first half.
'As far as strike force is concerned, you don't look any further than Luis Suarez and Daniel Sturridge in the English Premier League,' former England and Liverpool great Robbie Fowler tells Manu Shankar.
Liverpool captain Steven Gerrard has criticised what he called FIFA's political decision not to include former team mate Luis Suarez on their shortlist for this year's Ballon d'Or award as the world's best footballer.
England captain Wayne Rooney will be left out of the starting lineup for their last Euro 2016 Group B match against Slovakia.
Beer-swilling English football fans bathed in public fountains on Thursday evening in the northern France town on Lille to celebrate their team's victory over Wales in nearby Lens, with little sign of the tensions seen there in previous nights.
Christian Benteke struck twice to inspire Aston Villa to a shock 3-1 win at Arsenal on a dramatic opening day of the Premier League season on Saturday. Striker Daniel Sturridge scored and new goalkeeper Simon Mignolet saved a late penalty to earn Liverpool a deserved 1-0 win over Stoke City.
Costa Rica marched into the second round of the World Cup after topping Group D, containing three former winners, after a 0-0 draw with already-eliminated England on Tuesday.