The Belgian extinguished hopes of an all-Williams final by storming into the last four with a 6-4, 3-6, 6-3 victory over Serena.
Maria Sharapova squeezed in a victory between downpours at Wimbledon on Saturday, beating Ai Sugiyama of Japan 6-3 6-3 to book her place in the fourth round.
Jelena Jankovic finally ended a losing run against Maria Sharapova to claim her first grasscourt title.
The Russian won back-to-back matches on Saturday to reach the semi-finals of the Birmingham Classic.
The Indian ace was shown the door by the eighth seeded Italian in the second round of the Birmingham DFS Classic.
A competitive streak as hard as a diamond gave the 20-year-old the strength to stage a great escape at the French Open.
Maria Sharapova was given a brief scare on her way to a 6-1, 6-4 victory over Russian Alla Kudryavtseva in the French Open third round.
Maria Sharapova showed there was no room for sentiment on Wednesday when she led a trio of Russian seeds into the second round of the French Open.
The loss of the top two seeds was another huge blow to the Advanta Championships which has already seen the withdrawal of Venus and Serena Williams.
The Russian won the Istanbul Cup after her opponent Aravane Rezai retired hurt.
Fourth-seeded Venus Williams outpowered Bulgarian Tatiana Poutchek 6-1 6-2 to move into the second round of the Istanbul Cup on Tuesday.
Following Iga Swiatek's victory over Coco Gauff in the final, here's a list of French Open women's singles champions:
The Russian freely admits that a desire to build on a successful start to her career is fuelled by the prospect of an ever-expanding bank account.
Amelie Mauresmo received an easy passage into the final of the Advanta Championships in Philadelphia on Saturday when Maria Sharapova was forced out of the event with a sore shoulder.
List of US Open women's singles champions, since 1912.
Henin-Hardenne out-hit fellow-Belgian Kim Clijsters in the first semi-final, while Mauresmo beat Maria Sharapova.
Top seed Amelie Mauresmo, second seed Kim Clijsters and number three Justine Henin-Hardenne also won their quarter-finals.
The defending women's champion was dumped out of the U.S. Open by fellow-Russian Ekaterina Bychkova.
The Indian will take on seventh seed Elena Dementieva in the first round at Wimbledon
Serena Williams crushed top seed Maria Sharapova 6-1, 6-1 to reach the last eight.
Top seed Maria Sharapova dodged the showers on her way to a 6-3, 6-2 victory over Taiwan's Chan Yung-Jan to set up a third round encounter against Venus Williams at the Sony Ericsson Open on Saturday.
The Russian clinched her first Birmingham Classic title, beating surprise finalist Jamea Jackson in a close fought match.
Vera Zvonareva sent world number one Maria Sharapova to a stunning 4-6, 7-5, 6-1 at the Pacific Life Open.
Amelie Mauresmo and Maria Sharapova lost their respective fourth round matches at the French Open
Martina Hingis cruised but top seed Maria Sharapova had to work a little harder to secure opening victories at the Pacific Life Open.
Top seed Amelie Mauresmo, Kim Clijsters and Martina Hingis also revelled in improved conditions following the rain-soaked start to the French Open.
The ruthless American needed less than an hour to defeat Sharapova 6-1, 6-1 and notch her 19th consecutive win over the Russian in what some charitably dub a "rivalry."
The world number two suffered a surprise defeat by the Russian in the last 16 of the Italian Open.
List of Wimbledon women's singles champions since 1922.
Maria Sharapova retired during her Pan Pacific Open semi-final against Ana Ivanovic due to a hamstring injury.
Former world number one Hingis, chasing a record fifth Pan Pacific crown, reached the last four by pulverising Australia's Samantha Stosur 6-0 6-1.
Maria Sharapova responded to a scolding from her coach to beat Italy's Francesca Schiavone 7-5, 2-6, 6-1.