The former world number one duo had been sidelined from competitive action post the Paris Olympics due to Satwik's shoulder injury.
In the upcoming German Open, Lakshya Sen will spearhead India's challenge at the Super 300 tournament.
HS Prannoy breezed into the quarter-finals with a stunning straight-game win over former world champion Loh Kean Yew of Singapore but it was curtains for Kidambi Srikanth at the Japan Open Super 750 tournament.
Seventh seed Sindhu lost 14-21 18-21 to Bing Jiao in the women's singles.
Expectations from the Indian male shuttlers will also be high, given their exploits in recent months.
Srikanth made a good start in the second game, moving to 7-3 advantage but Lee once again turned the tables, jumping to 13-9 and kept his nose ahead to eventually shut the doors on the Indian.
Defending champion Lin Dan of China and top-seed Malaysian Lee Chong Wei advanced to the second round after notching up straight-set wins over their rivals in the World badminton Championship in Paris on Monday.
India's national champion Chetan Anand and World Championships quarter-finalist Anup Sridhar are seeded 11 and 13 respectively in the men's singles.
The Bangalore lad shocked world No 12 Shoji Sato of Japan in a quarter-final match at the Yonex-Sunrise Asian Badminton Championship.
The national women's champion has been top seeded for the Asian Satellite Badminton Championship in Jaipur..
Indian shuttlers Kidambi Srikanth and H S Prannoy advanced to the second round of the men's singles competition at the US$ 1,000,000 Indonesia Super Series Premier in Jakarta, on Wednesday.
The Chinese was given a tough time by unseeded Malaysian Lee Tsuen Seng before making the semi-final in the All-England badminton.
Two-time Commonwealth Games gold medallist Saina Nehwal continued her impressive run, progressing into the women's singles semi-finals with a straight-game win over unseeded Korean Lee Jang Mi at the Asia Badminton Championship in Wuhan, on Friday.
Defending champion Saina Nehwal entered the pre-quarterfinals but it turned out to be a disastrous day for the men with all of them, including reigning champion K Srikanth, failing to cross the opening hurdle at the Yonex-Sunrise India Open Super Series badminton.
Saina Nehwal is better equipped to win a medal in Rio in August than the Indian shuttler was when she claimed a bronze at the London Olympics four years ago, former All England champion Prakash Padukone said.
Italy's renowned World Cup winner Alessandro Del Piero has called the Indian Super League football tournament an 'adventure' and said he was 'enthusiastic' about embarking on this new journey.
Making their first appearance in the WTA Finals in Singapore, Sania Mirza and Cara Black outplayed Raquel Kops-Jones and Abigail Spears in their opening match to book their semi-finals berth on Thursday.
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