Balotelli made his debut for his hometown club after completing a four-match suspension that he was handed at Olympique de Marseille last season, while the visitors were without Cristiano Ronaldo as he recovers from injury.
In Pep Guardiola's 100th match in charge of the Manchester club, captain De Bruyne led from the front as City outclassed the Gunners, who have now suffered six home games without a win. Images from the EPL matches played on Sunday.
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
Images from the EPL matches played on Saturday
Tottenham Hotspur reached the semi-finals of the Champions League on away goals after a 4-3 (aggregate 4-4) defeat to Manchester City in a breathtaking quarter-final second leg game on Wednesday.
Images from the EPL matches played on Saturday
IMAGES from the English Premier League matches played on Saturday.
He increasingly looks like a manager unable to cope with the modern tactical realities of football. His display of a fear of failure has been appalling to watch. But Mourinho getting the sack at this juncture will hardly solve the problem, says Dhruv Munjal.
Ole Gunnar Solskjaer continued his dream start as Manchester United caretaker manager with a 3-1 Premier League win over Huddersfield on his Old Trafford debut in the dugout on Wednesday.
Thomas Meunier volleyed a spectacular last-minute goal to give Paris St Germain a 2-1 win at FC Basel, which took them into the last 16 of the Champions League on Tuesday.
IMAGES from Saturday's English Premier League matches.
A summary of Tuesday's matches in the UEFA Champions League.
A summary of Thursday night's UEFA Champions League matches.
A summary of Tuesday night's matches in the UEFA champions League.
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