Real Madrid edged past Sporting Lisbon 2-1, while Juventus came from behind to secure a 3-1 win at Sevilla and Borussia Dortmund crushed Legia Warsaw 8-4 to set a record for the most goals scored in a Champions League match.
Isco scored in the sixth minute of stoppage time as Spain launched an improbable fightback to snatch a 2-2 friendly draw against England with both their goals coming after the 89th minute at Wembley on Tuesday.
Wales continued their unbeaten start to the Euro 2016 campaign as a nervy 2-1 triumph over Cyprus, after they had been reduced to 10 men, bolstered the nation's dream of qualifying for a major championship finals for only the second time.
A round-up of Wednesday's league stage matches in the UEFA Champions League.
Images from the Champions League matches played on Wednesday
With eight teams remaining at Euro 2016, a guide to the form of the quarter-finalists, looking at their strengths and weaknesses.
News of all that's transpired on and off the football field
IMAGES from the Champions League matches played on Tuesday
News of all that's transpired on and off the football field
Images from Champions League matches played across Europe on Tuesday