The Manchester United striker has been ruled out with a hernia and will undergo surgery next week.
The game was United's first of a four-match tour of the U.S.
Manchester United suffered their first defeat under interim manager Ralf Rangnick, falling to a 1-0 loss at home to Wolverhampton Wanderers in the English Premier League on Monday.
The holders swept into the quarter-finals with a 2-0 victory.
A weakened Manchester United were beaten 2-1 at home by Leicester City on Tuesday, ending Manchester City's wait to be crowned Premier League champions.
Pochettino picks Barcelona as favourites to win Champions League
Saturday's 2-1 FA Cup quarter-final defeat at Wolverhampton Wanderers followed a 2-0 loss at Arsenal last week.
Manchester United's Premier League match against Liverpool was postponed on Sunday after United fans forced their way into the stadium and stormed the Old Trafford pitch to protest against the club's owners - the Glazer family.
Paul Pogba faces a race against time to prove his fitness for Monday's Premier League clash against Arsenal
Second-placed Manchester United edged closer towards qualification for the Champions League
'I cannot wait to play at Old Trafford in front of a full stadium and see all the fans again.'
Five talking points from the Premier League weekend:
The win extends United's unbeaten run in all competitions to 14 matches and secures a 30th appearance in the last four of the FA Cup for the club.
After a string of middling transfer windows, Manchester United have made their biggest statement of intent in recent years by signing centre back Raphael Varane and winger Jadon Sancho.
Manchester United midfielder Paul Pogba has thanked Jose Mourinho for helping him 'improve as a person' despite the breakdown of their relationship in the last few months leading up to the former manager's sacking on Tuesday.
Dean Henderson arrived at the club from Carlisle United at the age of 14,
Manchester United coach Ole Gunnar Solskjaer berated his team for their under par performance in the first half in their FA Cup semi-final first leg loss to cross-town rivals Manchester United
Paul Pogba's future at Manchester United caught up in a swirl of speculation.
Pogba said last month that he could seek a new challenge after three years at United, while his agent recently told The Times that the 26-year-old intends to leave the club amid reports linking him to Juventus and Real Madrid.
Mohamed Salah hit a hat-trick as Liverpool humiliated Manchester United, romping to a stunning 5-0 victory at Old Trafford in the Premier League on Sunday that leaves Ole Gunnar Solskjaer's future in serious doubt.
'We haven't managed to get ourselves in the top four. We needed other teams to help us out and we needed to help ourselves and we haven't done that'
Goalkeeper De Gea was forced to leave the field during Spain's Euro 2020 qualifier against Sweden on Tuesday.
Pep Guardiola said Manchester United's home ground Old Trafford is no longer the fortress it used to be as City look to win all three points and take the lead in the Premier League title race.
'We won at Tottenham away, Chelsea away, then Arsenal in the FA Cup, now this game today. What else does he have to do?'
As the Premier League resumes following the international break all eyes will be on Cristiano Ronaldo's homecoming party at Old Trafford on Saturday, with the Portuguese international set to resume his Manchester United career after 12 years away.
'My ancestors and my parents suffered for my generation to be free today, to work, to take the bus, to play football'
United are unbeaten in all competitions since Solskjaer replaced Jose Mourinho in December and their improvement is down to the Norwegian's insistence on an attacking style of play, as opposed to the defensive fare served up by his predecessor.
News of all that transpired on and off the football field.
A summary of Saturday's action in the Premier League.
English Premier League champions Manchester City cruised to a 2-0 win over struggling Manchester United in their derby at Old Trafford on Saturday.
Martial scored his 23rd goal for United in all competitions this season against LASK Linz in Wednesday's Europa League last-16 victory.
Manchester City reached their fourth straight League Cup final as second-half goals from John Stones and Fernandinho gave Pep Guardiola's side a 2-0 win over Manchester United in Wednesday's semi-final at Old Trafford.
AC Milan grabbed a 1-1 draw at Manchester United in the blockbuster Europa League last-16 first-leg at Old Trafford on Thursday.
Liverpool's first loss of the season means they cannot finish the campaign unbeaten to match Arsenal's 'Invincibles' of 2003-04.
The Spaniard has made a number of uncharacteristic mistakes in recent games, including one that allowed Chelsea to equalise in Sunday's 1-1 draw.
An early own goal by Luke Shaw, who deflected in a header from Luis Suarez, decided a tight first leg and gave Barca their first victory at Old Trafford in five attempts in European competition.
Timo Werner scored his first goal of the season as a much-changed Chelsea side crept into the fourth round of the League Cup by beating Aston Villa 4-3 on penalties after the Stamford Bridge clash ended 1-1 on Wednesday.
Solskjaer is also hoping to keep hold of striker Odion Ighalo until the end of the season.
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