Borussia Dortmund stayed top of the Bundesliga by beating Augsburg 4-3, while titleholders Bayern Munich were thumped 3-0 at home by Borussia Moenchengladbach.
The Bavarians have now won the German league title a record 29 times.
Europa League favourites Manchester United secured a 1-1 draw on a threadbare pitch at Rostov, while Olympique Lyonnais beat AS Roma 4-2 helped by a fine individual goal from Nabil Fekir in their last 16, first leg ties on Thursday.
Images from the UEFA Champions League matches played across Europe on Wednesday
Tottenham Hotspur's Europa League hopes were crushed by mid-table Belgian side Gent, who booked their spot in the last 16 with a 2-2 draw at Wembley on Thursday as the hosts paid the penalty for Dele Alli's first-half red card.
News of all that's transpired on and off the football field
Bayern Munich secured a record fourth consecutive Bundesliga title with a game to spare after a 2-1 victory at Ingolstadt on Saturday helped them put the disappointment of their midweek Champions League semi-final exit behind them.
"We are pleased with the win, the many chances and the 70,000-plus spectators."
Thomas Mueller and Thiago Alcantara struck twice as Bundesliga leaders Bayern Munich thumped Werder Bremen 5-0 on Saturday to open an eight-point gap at the top with their first win in three games. The Bavarians, who claimed one point from their previous two matches, terrorised visiting Werder with Kingsley Coman setting up three goals in an eye-catching dress rehearsal for the Champions League last-16 second leg against Juventus next week. "It may look easy ... but it was not," said Bayern coach Pep Guardiola. "It was important to win after losing to Mainz 05 (last week). "As for Kingsley, he is a young player but today he showed his quality. We will need such a player on Wednesday." Guardiola can also count on Mario Goetze again after the attacking midfielder made his comeback from a four-month injury layoff.
The Bundesliga enjoyed a bumper afternoon of stunning goals and penalty drama on Saturday with Hakan Calhanoglu's viciously swerving 40-metre free kick for Hamburg SV the pick of the bunch.
A weekend of surprise results across Europe's big leagues saw Bayern Munich's unbeaten run come to an end, Napoli knocked off top spot in Serie A and Manchester City toppled in the Premier League where Leicester City are the new leaders.
In other matches, VfL Wolfsburg edged past Hertha Berlin 2-0; promoted Ingolstadt snatched a last-gasp 1-0 win at Werder Bremen
The win lifted Hamburg, who needed a relegation playoff to stay up last season, to seventh on six points.
An 85th-minute equaliser by Naldo gave VfL Wolfsburg a 2-2 draw at Borussia Dortmund, maintaining their hold on second place and leaving the hosts in the Bundesliga relegation zone.
Real Madrid are determined to create an intimidating atmosphere for visitors VfL Wolfsburg as they try to overturn a two-goal deficit in Tuesday's Champions League quarter-final second leg at the Santiago Bernabeu stadium.
Photos from the Champions League matches played on Wednesday.
Bayern Munich have all but secured their third consecutive Bundesliga title and victory over Hertha Berlin could see them clinch it as early as this weekend.
Thomas Mueller scored twice as Bundesliga leaders Bayern Munich came from a goal down to beat Hanover 3-1 on Saturday and stretch their advantage at the top to 11 points after VfL Wolfsburg slumped to a 1-0 loss at Augsburg.
Photos from the Champions League matches played across Europe on Tuesday
News of all that's transpired on and off the football field
United's Ibrahimovic, Roma's Dzeko find the net thrice to give clubs first leg advantage
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Bayern Munich had to put their Bundesliga title celebrations on hold on Saturday after beating gutsy Mainz 05 2-0 while Borussia Dortmund also won, 3-0 at Hanover 96.
Bayern Munich humiliated former Bundesliga powerhouses Werder Bremen 7-0 on Saturday with Franck Ribery scoring twice and setting up another two as the champions kept up their seemingly unstoppable march towards another title.
Bayern Munich went top of the Bundesliga with a 1-1 draw at Bayer Leverkusen on Saturday as rivals Borussia Dortmund slumped to their first defeat of the season with a 2-0 reverse at Borussia Moenchengladbach.
The good news for Schalke 04's defenders as they prepare to face Chelsea in their opening Champions League Group G match on Wednesday is that striker Diego Costa is nursing a slight hamstring injury.
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
Robert Lewandowski scored a brilliant free kick to give Bayern Munich a 1-0 win over Atletico Madrid in their last Champions League Group D outing on Tuesday, ending the 100 percent record of their opponents. The Poland international curled the ball over the wall and into the corner of the net in the 28th minute but the goal had no impact on the final standings with Atletico guaranteed top spot and Bayern in second place.
Anthony Martial went from villain to hero as his second-half equaliser earned Manchester United a deserved point in a 1-1 draw against CSKA Moscow in Champions League Group B on Wednesday.