De Minaur, 20, went the entire tournament without facing a break point, and the Australian fittingly clinched victory with a deft serve-and-volley backhand winner.
Ramkumar Ramanathan's good run at the Chennai Open continued as he combined with compatriot N Sriram Balaji to knock out fourth seeded Kiwi pair of Artem Sitak and Marcus Daniel on Wednesday and storm into the doubles quarter-finals.
Defending champion Petra Kvitova used a dominant serve to beat Lucie Safarova 6-7(6), 6-2, 6-2 in their all-Czech final at the Connecticut Open on Saturday.
Images from Saturday's action at the Australian Open.
The top-seeded Serb, who had not dropped a set in four matches since the round of 16 at the Australian Open in January, looked out-of-sorts throughout the 98-minute contest.
Czech defending champion Katerina Siniakova fended off Maria Sharapova in a fiercely contested match at the Shenzhen Open on Friday to set up a final with world number one Simona Halep.
Former champion Stan Wawrinka battled past Russian fourth seed Daniil Medvedev in five sets to reach the Australian Open quarter-finals with a 6-2, 2-6, 4-6, 7-6(2), 6-2 victory. Fifth seed Dominic Thiem kept his flawless record against Gael Monfils intact with a trouble-free 6-2, 6-4, 6-4 victory on Monday to reach his maiden Australian Open quarter-final.
Summary of sports events and persons who made news on Wednesday
Federer, who skipped the entire clay court season after winning the Australian Open and claiming titles at Indian Wells and Miami this year, will next play defending champion Florian Mayer who beat Frenchman Lucas Pouille in three sets.
Bernard Tomic is set to sit out the Australian Open after Tennis Australia (TA) decided not to award him a wildcard to the main draw, the organisers said on Thursday.
Images from Day 1 of the Australian Open, in Melbourne, on Monday.
A summary of Day 2 at Wimbledon on Tuesday.
Images from the Australian Open matches played at Melbourne Park on Wednesday.
Former world number one Andy Murray withdrew from the Brisbane International with a hip problem on Tuesday, further putting in doubt the Briton's prospects of being fit in time for the Australian Open later this month.