India have won a record 12 successive Test series at home, losing only one of the last 35 matches they have hosted. It includes a 4-0 series victory in England's previous tour in 2016-17.
England are also the last team to have triumphed in India in 2012-13 when Root, who will be playing his 100th Test on Friday in Chennai, made his debut.
England blanked Sri Lanka 2-0 last month but their decision to rotate multi-format players undermines their prospects in India.
Six players to watch when India host England in a four-match Test series which begins on February 5:
If there were any doubts about whether Pant was ready for a regular run in the Test side, they were wiped out after his series-clinching performance in Australia.
The diminutive but fearless left-hander was unlucky to miss out on two centuries but his unbeaten 89 in the fourth innings chasing 328 in the decider at the Gabba helped catapult him to 13 in the world batting rankings, the highest-ranked wicketkeeper.
Should the technically superior Wriddhiman Saha get the nod for keeping wickets, the 23-year-old Pant appears to have done enough to earn his place in the side as a specialist batsman.
Two fifties in Gill's debut series against Australia's attack, including an elegant 91 at the Gabba, have given an indication that he could be the answer to India's opening woes in the long run.
The assured 21-year-old looked at home against the short ball that has long troubled Indian openers in the past and he could cement his position at the top of the order if he continues to deliver on home soil.
England will be relieved to see the wily Ravindra Jadeja miss the first two Tests with injury but will be wary of Ashwin leading the spin attack after the off-spinner claimed a series-high 28 wickets when England last toured India in 2016.
The first two Tests are also on his home track in Chennai, where he picked up 12 wickets in a match against Australia in 2013.
Ashwin missed the Gabba Test with a back injury after a heroic batting effort in Sydney to force a draw and India can count on the veteran player to provide batting depth.
After being rested for England's tour of Sri Lanka, Archer returns to the Test side for the first time since their home summer where the 25-year-old was underwhelming and hit the headlines for breaching COVID-19 protocols.
Archer can trouble any top order with his searing pace and bounce. The Barbados-born quick has no experience bowling with the red ball on sub-continental pitches but is familiar with the conditions following his Indian Premier League stints.
Stokes returns to the side after a period of rest and he will look to build on his successful home summer during which he top-scored with 363 runs in five innings in the series against the West Indies.
Stokes, who is no stranger to Indian conditions having played in the Indian Premier League, is the world number one all-rounder and will be hungry for revenge after England were convincingly beaten 4-0 on his last visit in 2016.
The England opener has not had the best preparation going into the India tour having skipped the Sri Lanka series to attend the birth of his child, but he could reclaim his spot following Zak Crawley's struggles.
Crawley managed only 35 runs in four innings against an inexperienced Sri Lankan attack and Burns opening the batting alongside Dom Sibley gives England a better chance of unsettling India's formidable pace attack with a left-right combination.