Sevilla last week lost a crucial game 1-0 at home to Valencia, who are fifth, but fared better this time as Mesa gave them the lead with an exquisite first-time finish into the far top corner in the 41st minute.
Former Sevilla coach Joaquin Caparros and current Granada manager Paco Jemez both said earlier on Thursday that they were interested in the position if Del Bosque was to leave.
Outgoing Spain coach Vicente del Bosque has no regrets as he prepares to leave his post at the end of July after eight years in charge during which they won the World Cup and Euro 2012.
News of all that's transpired on and off the football field.
La Liga leaders Barcelona moved 10 points clear with a 4-1 win at Real Betis on Sunday after second place Atletico Madrid slipped up at Athletic Bilbao on Saturday in a 2-0 defeat.
The suggestion that Spain need to change their playing style is already meeting resistance even though another disappointing performance at a major soccer tournament suggests that tiki-taka has run its course. In many countries, a defeat as comprehensive as the one Spain suffered against Italy in Euro 2016 on Monday, when they were outplayed and lucky to lose only 2-0, would have led to calls to knock everything down and start again. In Spain, however, where many are proud of having such a distinctive style of play, there are plenty of voices calling for the team to continue trying to pass the ball all the way into the goal.
Barcelona forward Ousmane Dembele scored twice and produced a mesmerising display to fire his side to a 5-1 win over Villarreal on Wednesday which stretched the champions' unbeaten run this season to 36 games with two remaining.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field