Barcelona suffered a first home defeat of the season when they lost 3-2 against Valencia after finishing with 10 men in La Liga on Saturday, leaving the door open for Madrid rivals Atletico and Real to move above them.
Cristiano Ronaldo's Champions League debut for Juventus lasted only 29 minutes as he was red-carded but the Italians began their Group H campaign impressively with a 2-0 victory at Valencia on Wednesday. Penalties either side of halftime by Miralem Pjanic sealed the points for the visitors as Valencia's return to European competition after a two-year absence fell flat.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Second-half headers from Diego Godin and Raul Garcia gave holders Atletico Madrid a 2-0 win over Valencia and a place in the King's Cup quarter-finals by 3-1 on aggregate.
Alvaro Negredo struck in stoppage-time as stuttering Valencia won 2-1 against his former club Sevilla on Sunday to earn coach Pako Ayesteran victory in his first home game in charge since succeeding Gary Neville.
Arsenal's Pierre-Emerick Aubameyang struck a vital late goal to seal a 3-1 win over Valencia on Thursday and give his side breathing space for the second leg of their Europa League semi-final in Spain next week.
Real Madrid's unbeaten start to the La Liga season came to an abrupt and surprising end as Real Mallorca claimed a stunning 1-0 victory at a rocking Son Moix on Saturday to climb out of the relegation zone.
IMAGES from the Champions League matches played on Tuesday
A Neymar double and a clinical finish from Luis Suarez handed Barcelona a comfortable 3-0 victory over BATE Borisov that put them on the verge of qualifying for the last 16 of the Champions League for the 12th consecutive season.