World No 1 Sania Mirza and her Czech partner Barbara Strycova were ousted from the women's doubles after losing to top seeds Caroline Garcia and Kristina Mladenovic in the quarter-finals of the US Open, in New York.
The French pair won 7-6(7-3), 6-1 in only 69 minutes to end the Indian challenge at Flushing Meadows.
The other Indians in the fray -- Rohan Bopanna, Leander Paes and Saketh Myneni -- lost their respective matches in the earlier rounds.
Both pairs traded a break each in the first set after which they held serve to take it to the tie-breaker.
The seventh seeded Indo-Czech pair lost serve in mini-service break as they conceded the first set 7-6 in 45 minutes.
The second set was a virtual cakewalk for the French girls, who broke serve twice to open up an unassailable 5-0 lead before finishing the match at 6-1.
In the mixed doubles, the pair of Sania and Ivan Dodig were knocked out by Barbora Krejcikova and Marin Draganja in the second round.