Tottenham Hotspurs ended their 15-year wait of beating Manchester United at White Hart Lane as they thrashed Louis Van Gaal’s side 3-0 on Sunday.
The home side scored three times in the space of six second-half minutes to move to within seven points of the league leaders Leicester City, while Man United remain fifth, four points from the Champions League positions.
After a flat first half in which Lamela missed an open goal, Spurs broke the deadlock after 70 minutes when Dele Alli fired home Christian Eriksen's low cross.
Alderweireld rose to head in Lamela's free kick four minutes later and Lamela swept in a third for a rampant home side who remain the only possible threat to Leicester City's march towards the title.
Fifth-placed United managed only one shot on target as their hopes of a Champions League spot suffered a severe blow.
Vardy scores brace as Leicester thrash Sunderland
Premier League leaders Leicester City moved even closer to the title by winning 2-0 at relegation-threatened Sunderland on Sunday.
England international Jamie Vardy put them ahead in the 66th minute and he added his second -- and 21st of the season -- in added time.
That left them 10 points ahead of second-placed Tottenham Hotspur, who play Manchester United later on Sunday.
With five games left, Claudio Ranieri's unfashionable side need a maximum of nine more points to become English champions for the first time.
Sunderland remain in the bottom three, four points behind Norwich City, who they play next Saturday.
"It was tough, we knew it would be, but we ground it out," Vardy told Sky Sports. "We know it's a step closer but you never know what can happen.
"The main thing now is we've got to take it into the next week."
Since beating Sunderland 4-2 in his first match in charge last August, Ranieri has stayed true to his beliefs -- taking nothing for granted.
"Of course nobody could have believed it," he said of imagining a title success on that first day of the new campaign.
"It's amazing and I want to thank everyone (of our fans). We moved Leicester to Sunderland."
Sunderland manager Sam Allardyce was disappointed with the way his team conceded two goals to Vardy, after warning his defenders of precisely that outcome.
"We switched off once and allowed Jamie Vardy to do what we said was his main strength," he told Sky.
That was the moment midway through the second half when experienced defender Younes Kaboul failed to deal with Danny Drinkwater's long ball.
Vardy latched onto it and went on to beat goalkeeper Vito Mannone.
Substitute Jack Rodwell then missed Sunderland's best chance to equalise and despite being thwarted once by Mannone, Vardy went round him to seal victory in stoppage time.
Liverpool routs Stoke City 4-1
Liverpool romped to an easy victory over Stoke City on Sunday despite manager Juergen Klopp resting a number of players ahead of Thursday's second leg of the Europa League quarter-final against his former club Borussia Dortmund.
Klopp made seven changes from the side that had drawn 1-1 in Germany, giving first Premier League starts to youngsters Kevin Stewart and Sheyi Ojo.
Ojo set up the second goal for Daniel Sturridge with a fine cross and when he was substituted at halftime, replacement Divock Origi scored twice. Earlier Alberto Moreno had put the home side in front before Bojan Krkic equalised.
The victory sent Liverpool above Stoke into eighth position, one point ahead of them but nine short of the Champions League places.