"They have played very well to beat the Australians but they are not unbeatable and the conditions in Pakistan will not suit them," he told Reuters on Friday.
"They will face totally different conditions and it will be a hard series and tour for them, particularly their bowlers."
England are due to arrive in Pakistan on October 26 to play three Tests and five one-day internationals.
It will be their first tour after completing a 2-1 victory over Australia last Monday and their first in Pakistan for five years. England, led by Nasser Hussain, won that Test series 1-0 in 2000.
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"We are already preparing hard for England. Because we know they have a good combination but are not invincible and we have to work hard to beat them," he said.
"If our fast bowlers are not hundred percent fit, then attacking them with spin is an option because our conditions favour slow bowlers."
Inzamam added that recalling leg spinner Mushtaq Ahmed for the series was a option which was under review.
Mushtaq has performed well for English county Sussex for the last three seasons but has not been considered by the Pakistani Test selectors since October 2003 against South Africa.
The 35-year-old, who has 185 wickets in 52 Tests, has been displaced by Danish Kaneria in the senior team.
