The Manchester United striker has been ruled out with a hernia and will undergo surgery next week.
With five goals to his name, and none to challenge him, the Czech Republic's striker is on course towards claiming the golden boot award.
Holland coach Dick Advocaat has opted for Manchester United striker Ruud Van Nistelrooy to lead the attack against Germany.
Lionel Messi completed a hat-trick to earn 10-man Barcelona a 3-3 home draw with Real Madrid.
Real Madrid drew 1-1 at home with local rivals Getafe in the Bernabeu.
Besides Nistelrooy, Manchester United will also be assisted by the fit-again pair of Louis Saha and Cristiano Ronaldo, while Paul Scholes has completed a three-match ban.
They say never go back, but United fans had been longing for Ronaldo to rejoin their side for many years, more in forlorn hope than anything else.
The 1-0 victory gave Chelsea top slot in the premier league, ahead of Arsenal.
Dutch striker Ruud van Nistelrooy said that his two goals in Real Madrid's 5-1 thrashing of Dynamo Kiev were the perfect way to cap a memorable day that began with him becoming a father.
Ryan Giggs scored both times for Manchester United; Harry Kewell pulled one back for Liverpool.
They beat Olympique Lyon 2-1 to give manager Alex Ferguson a "fantastic night" in his 1,000th game.
Ruud van Nistelrooy scored a hat-trick as Real Madrid thrashed Levante 4-1.
The Dutch striker scored twice in a 2-0 victory over Charlton Athletic in the English premier league.
Ruud van Nistelrooy and Paul Scholes gave them a 2-1 win over Newcastle United in the English Premiership.
Man U's impressive pre-season tour of the US continued with a comfortable 3-1 victory over Mexico's Club America.
The game was United's first of a four-match tour of the U.S.
Fear of further semi-final failure is all that stands in the way of a classic when slick-passing Portugal meet a fast improving Netherlands side.
The modest Swede believes Ruud van Nistelrooy will be the best striker on the pitch in Saturday's quarter-final against the Netherlands.
The Manchester United striker finished with one more goals than last season's winner, Thierry Henry.
They beat Millwall to win the FA Cup final 3-0 and lift the trophy for a record 11th time.\n\n
Manchester United have dismissed speculation that their leading scorer is on his way to Barcelona or Real Madrid.
Striker Ruud van Nistelrooy's opportunistic goal gave them a 1-0 victory over Birmingham City in the English premiership.
The Manchester United captain believes the club needs a new striker to partner Dutchman Ruud van Nistelrooy upfront.
They crushed Charlton Athletic to move eight points clear of Arsenal at the top of the English premiership.
Manchester United's 3-0 victory over Fulham gave them the top spot in the English premier league.
Alex Ferguson blamed his wholesale changes for the team's failure to set a club record six Champions League wins in a row.
A perfect header from substitute Shaun Goater three minutes from time earned Manchester City a 1-1 draw in the English premier league.
In his new book Leading, the most successful manager in British football history said that does not mean he would do anything differently.
A round-up of Saturday's action in LaLiga, Ligue 1 and Serie A.
Arsene Wenger often says he has no time to look back because he is so focused on the future but he spent a minute reminiscing on Friday on the 10th anniversary of the defeat to Manchester United that ended Arsenal's famous 49-match unbeaten run.
Leicester City striker Jamie Vardy was officially presented with Guinness World Records certificate in honour of his 11 game record goal-scoring run in the English Premier League.
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