England defender John Stones has been ruled out of their final two Euro 2016 qualifiers through injury, the FA said in a statement.
Barcelona dropped their first points of the La Liga season as their star-studded forward line misfired in a 0-0 draw away to Malaga on Wednesday.
Barcelona's Lionel Messi was at the heart of another devastating attacking show.
A subdued Fernando Torres helped Atletico Madrid to a 2-0 win over local rivals Real in the first leg of their King's Cup last-16 tie on Wednesday in his first start since his return to his boyhood club.
Gijon spoiled Asier Illarramendi's return to Real Sociedad's midfield after rejoining from Real Madrid this week when they held the Basque club, coached by Scot David Moyes, to a 0-0 draw in San Sebastian.
A much-changed Real Madrid ground out a 2-0 victory at third-tier Fuenlabrada in their King's Cup last-32 first leg on Thursday, needing two dubious penalties to break down their stubborn hosts as both sides finished with 10 men.
Lopetegui blends youth and experience in Spain World Cup squad
As Barca prepare for a trip to Madrid to play Rayo Vallecano on Saturday, they are still reeling from Tuesday's 3-2 Champions League reverse at Paris St Germain, when their defence was badly exposed by the Ligue 1 title holders.
Barcelona's talismanic Lionel Messi remains the driving force of a talented side on the brink of repeating 2009's historic treble despite a change in their coach and style of football, not to mention a host of players.
The Portuguese admitted he had over-stretched himself after having knee problems at the back end of the last season which he carried into the World Cup and then suffered a hamstring injury at the start of this campaign.
Barcelona closed in on the La Liga title by thrashing local rivals Espanyol 5-0 on Sunday as Atletico Madrid dropped out of the race after losing 2-1 at Levante and Real Madrid beat Valencia 3-2.
Lionel Messi came off the bench to preserve Barcelona's unbeaten run in La Liga with a sensational late equaliser in a thrilling 2-2 draw at Sevilla on Saturday as the runaway leaders came back from two goals down in the space of a minute.
News of all that's transpired on and off the football field
Real Madrid and Barcelona pulled two points clear in La Liga when Cristiano Ronaldo set a club scoring record in Real's 3-0 stroll against Levante and Neymar hit four as Barca beat Rayo Vallecano 5-2 on Saturday.
Real Madrid extended their unbeaten run to 25 matches and rejoined Barcelona and Atletico Madrid at the top of La Liga when Jese, Karim Benzema and Luka Modric scored in a 3-0 win at Getafe on Sunday.
Lionel Messi was in inspired form as champions Barcelona hammered Celta Vigo 5-0 on Saturday, recording a fourth straight league victory which keeps them top of La Liga after Real Madrid had put the pressure on the Catalans with a 4-1 win at Eibar.
Barcelona coach Luis Enrique is head strong but it appears as though he may be fighting a losing battle with the four times World Player of the Year.
Real Madrid closed to within two points of La Liga leaders Barcelona after demolishing nine-man Rayo Vallecano 10-2 while Atletico Madrid missed a chance to seize top spot outright by losing 1-0 at Malaga.
Cristiano Ronaldo struck twice as leaders Real Madrid subdued Eibar 4-0 on Saturday while Lionel Messi set a La Liga record of 253 goals with a hat-trick in second-placed Barcelona's 5-1 rout of Sevilla.
Atletico Madrid's Brazilian striker Diego Costa scored twice as they came from behind to beat Levante 3-2 at home on Saturday to go three points clear at the top of La Liga.
Cristiano Ronaldo netted his 27th career hat-trick and Gareth Bale struck twice as Real Madrid bounced back in style from consecutive defeats with a thumping 8-2 La Liga win at Deportivo La Coruna on Saturday.
Neymar scored the opener to continue his rich vein of form as 10-man Barcelona won a one-sided La Liga derby against Espanyol.
A second-string Spain celebrated coach Vicente del Bosque's two-year contract extension with a 2-1 away win over Equatorial Guinea in a friendly on Saturday that was marred by an injury to Xabi Alonso.
Barca dominated possession and Luis Suarez had several early chances but it was Villarreal who took the lead with Denis Cheryshev redirecting a Mario Gaspar shot past keeper Claudio Bravo on the half hour.
'I feel as confident and motivated as at the beginning. I can't control rumours, but I still have faith'
A summary of all the Champions League matches played across Europe on Wednesday
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
Paris St Germain's Zlatan Ibrahimovic scored his first Ligue 1 goal this season before missing a penalty as they beat En Avant Guingamp 3-0 to extend their lead to four points on Tuesday.
Barcelona suffered a first home defeat of the season when they lost 3-2 against Valencia after finishing with 10 men in La Liga on Saturday, leaving the door open for Madrid rivals Atletico and Real to move above them.
Cristiano Ronald headed his 300th goal for Real Madrid in a laboured 2-0 La Liga victory at neighbours Rayo Vallecano on Wednesday that kept the gap on leaders Barcelona down to four points.
Diego Costa continued his rich vein of form as he helped leaders Chelsea to a 3-0 win over Aston Villa while Louis van Gaal enjoyed only his second Premier League win as Manchester United manager following a 2-1 victory against West Ham.
News of all that's transpired on and off the football field
Spain coach Vicente del Bosque has called Atletico Madrid's Brazil-born forward Diego Costa into his squad for the first time for this month's friendlies away to Equatorial Guinea and South Africa.
Real Madrid were the big winners in Spain as their success at Almeria was followed by a Barcelona draw and a surprise Atletico Madrid defeat.
Key head-to-head battles in Saturday's "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT)
News of all that's transpired on and off the football field
European champions Bayern Munich led the charge into the last 16 of the Champions League when they beat Viktoria Plzen 1-0 to chalk up a record-equalling ninth straight victory in the competition on Tuesday.
Cristiano Ronaldo grabbed a hat-trick and Gareth Bale became the fifth British player to score for Real Madrid at the Bernabeu in La Liga when he struck twice in an action-packed 7-3 win over Sevilla on Wednesday.
A summary of the results of the major European football league matches on the weekend.
Images from the 2018 World Cup qualifiers played in Europe on Monday