Spanish media reported that Real Madrid have bid 15 million euros for the Manchester United striker.
A profile of Ruud van Nistelrooy appeared on their website as if the Manchester United striker had signed for the club.
Dutch goalscorer Robin van Persie said his team was rewarded for hard work.
The Manchester United striker has been ruled out with a hernia and will undergo surgery next week.
Manchester United suffered a dispiriting 3-1 defeat at neighbours Manchester City in their 145th derby on Saturday to complete a painful week.
With five goals to his name, and none to challenge him, the Czech Republic's striker is on course towards claiming the golden boot award.
Holland coach Dick Advocaat has opted for Manchester United striker Ruud Van Nistelrooy to lead the attack against Germany.
Manchester beat Aston Villa 2-0 to slash Chelsea's Premier League lead to six points.
Besides Nistelrooy, Manchester United will also be assisted by the fit-again pair of Louis Saha and Cristiano Ronaldo, while Paul Scholes has completed a three-match ban.
The Netherlands consolidated their position at the top of Group One with a 4-0 World Cup qualifying rout of Andorra.
Champions League holders Liverpool beat Sunderland 1-0 as Xabi Alonso scored through a free kick.
The English Premiership side cruised to a 3-0 pre-season win over Chinese side Beijing Guo'an.
The 1-0 victory gave Chelsea top slot in the premier league, ahead of Arsenal.
Ryan Giggs scored both times for Manchester United; Harry Kewell pulled one back for Liverpool.
The Dutch striker gave Manchester United a 4-1 premier league win at Leicester City.
The Dutch striker scored twice in a 2-0 victory over Charlton Athletic in the English premier league.
Ruud van Nistelrooy and Paul Scholes gave them a 2-1 win over Newcastle United in the English Premiership.
Manchester United striker Ruud van Nistelrooy had a chance to thank knee surgeon Richard Steadman who saved his career.
Man U's impressive pre-season tour of the US continued with a comfortable 3-1 victory over Mexico's Club America.
The game was United's first of a four-match tour of the U.S.
The Manchester United striker finished with one more goals than last season's winner, Thierry Henry.
The Manchester United striker will undergo a scan on Friday as concern over his calf injury deepens.
They beat Olympique Lyon 2-1 to give manager Alex Ferguson a "fantastic night" in his 1,000th game.
Striker Ruud van Nistelrooy's opportunistic goal gave them a 1-0 victory over Birmingham City in the English premiership.
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