Both survived tough opening matches at the Pacific Life Open Masters Series.
The American won his third successive Stella Artois title with a tight 7-6, 7-6 victory over Croatian Ivo Karlovi.
After the win, Roddick said he was looking forward to the European claycourt season.
Top seeded Roddick beat Austria's Jurgen Melzer while Grosjean scored over Nicolas Lapentti in the semi-finals of the U.S. Men's clay court championships.
The Second seed Andy Roddick went through after Russian Nikolay Davydenko retired in the third set of their match because of breathing problems.
The beaten Wimbledon finalist has now lost six of his seven meetings with Federer, the world number one.. \n\n
The tennis ace may not have won a medal at the Olympics, but he learnt to say 'Efharisto poly.'
The top seed survived three match points before beating Ivan Ljubicic in the semi-finals of the RCA Tennis Championships.
The top seed won two matches on Thursday to advance to the last eight at the RCA Tennis Championships in Indianapolis.
Former champion Andy Roddick will take centre stage at the US Open on Friday, perhaps for the last time, when he plays rising Australian Bernard Tomic for a place in the third round.
Andy Roddick won the shootout between former champions when he squeezed past Lleyton Hewitt 7-6, 7-6 to reach the quarter-finals at Queen's Club on Thursday.
Andy Roddick blew away fellow American Robby Ginepri 6-2, 6-3 on Thursday to move into the third round of the Memphis Championships.
The American No. 2 scored a fluent win over Robert Kendrick U.S. Men's Clay Court Championships.
Andy Roddick beat Vince Spadea 6-1, 6-3, while Guillermo Coria beat Fernando Gonzalez 4-6, 7-6, 6-1 in the semi-finals of the Nasdaq-100 Open.
The American is quoted at 11-4 with compatriot Andre Agassi second favourite on 100-30.
Novak Djokovic's bid for a record 25th Grand Slam title kicked off on Monday with an easy win over qualifier Radu Albot in the US Open first round.
A new coach, a new work ethic and renewed belief in his game took Andy Roddick agonisingly close to a Wimbledon title on Sunday and while the experience left him utterly drained the American will not turn back the clock now.
Agassi clattered former Melbourne Park runner-up Thomas Enqvist 6-0 6-3 6-3 in a breathtaking display at the Australian Open.
The top seed toiled for more than two hours to overcome Todd Martin 7-6, 1-6, 7-5 in the first round of the Kroger St Jude tournament.
Sweden's Jonas Bjorkman defeated the world number one 6-3, 6-4 in just over an hour at the Qatar Open.
"People talk about power, power, power, but there's still more to our game," said the American.
The Briton unleashed a furious verbal volley at the umpire during his match after a spectator called out during a rally in the third set.
Roddick edged past Andre Agassi while Grosjean easily beat Tim Henman in the semis of the Stella Artois Championship.
The US ace broke his record with a 155mph (249kph) serve as the U.S. took a 2-0 lead over Belarus in their Davis Cup semi-final.
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