Gaudio has beaten Nadal three times out of four but the Spaniard won their most recent match in Monte Carlo this year.
While Spanish sensation Rafael Nadal silenced a partisan crowd with a win over French number one Sebastien Grosjean
Argentine Gaston Gaudio made a comfortable start to his French Open title defence by beating Frenchman Julien Benneteau 7-5, 6-0, 6-1 on Monday.
Tommy Haas and Alexander Waske rallied the Germans to a 2-1 win over favourites Argentina.
But fellow Argentines Gaston Gaudio and the indefatigable Guillermo Coria won in straight sets as did Russian Marat Safin
Last year's winner Carlos Moya was beaten 6-4, 7-6 by local wildcard Potito Starace.
The French Open champion overcame a mid-match slump to defeat Spaniard Tommy Robredo 6-1, 2-6, 6-1 in the final.
Gaudio beat Guillermo Garcia-Lopez in a three set semi-final at the Estoril Open while Robredo advanced after Carlos Moya retired.
The former French Open champion rolled back the years as he dumped fifth seed Nicolas Massu out of the Estoril Open on Wednesday.
French Open champion Gaston Gaudio said Spanish teenager Rafael Nadal is the biggest threat to his Roland Garros crown.
The Spaniard's revival continued with an enthralling 6-4, 4-6, 6-3 victory over Argentine Gaston Gaudio to earn a place in the semis of the Barcelona Open.
The top seed was dumped out of the Barcelona Open by Argentine Jose Acasuso in straight sets.
Gaston Gaudio beat Alberto Martin in straight sets to set up an all-Argentine final against wildcard Mariano Puerta in the Buenos Aires Open.
The 16th seeded Cypriot was a comfortable winner over Dane Kristian Pless while Sharapova proved too good for American Jill Craybas.
The world number one made a winning return from injury with a ruthless victory in the Masters Cup.
The French Open champion registered a 6-4, 6-3 victory over Jiri Novak in the quarter-final of the Stuttgart Cup.
The French Open champion made the grade after chalking up two contrasting wins on Thursday.
The Argentine beat compatriot and French Open champion Gaston Gaudio in the final.
Unseeded Gaston Gaudio fought back from two sets down and saved two match points to win the French Open.
The 22-year-old Swiss survived a tricky first-round match with flashes of brilliance and plenty of determination.
The world No. 1 scored the first 6-0, 6-0 win in the history of the Masters Cup, pulverising Argentine Gaston Gaudio, to move within one win of a third straight Masters crown.
The former world No. 1 reached the semi-finals of the Bellsouth Open at home in Chile.
The ninth seed who has won five titles this year offered little resistance and the American eased to victory in the first round at the US Open.
Spain's Fernando Verdasco came back from the brink of defeat to beat the top seed 6-7, 7-6, 6-4 in the last 16 of the Rome Masters.
The claycourt specialist won 6-4 6-4 as he followed up last week's win in Vina del Mar, Chile with another title, his first on home soil.
Top seeded Argentine Gaston Gaudio reached the final of the $380,000 Bell South Open on Saturday with a three-set win over Spain's David Ferrer.
Dominic Thiem produced a remarkable fightback to beat German fifth seed Alexander Zverev 2-6, 4-6, 6-4, 6-3, 7-6(6) to win the US Open for the first time on Sunday.
Rafael Nadal won his first title of the year with a 6-4, 6-1 victory.
The 32-year-old debutant at the ATP's blue riband event won the first 11 games of the round-robin clash before a relieved Nishikori finally got on the scoreboard with an angled winner.
List of French Open men's singles champions:
The 26-year-old has not always handled the expectations placed on his shoulders after he won the Wimbledon junior title in 2008 with a game style uncannily like Federer's.