The former Fulham footballer was one of the most gifted playmakers England ever produced.
The Dutch striker scored twice in a 3-2 triumph at Fulham.
The Premier League leaders preserved their 11-point lead with a 4-1 victory over Crystal Palace.
Aaron Ramsey indulged his new goalscoring habit on his return to his boyhood club as Arsenal opened up a seven-point lead at the top of the Premier League with a 3-0 victory at Cardiff City on Saturday.
United beat Leicester City at Old Trafford in the opening game of the season but Spurs present a very different quality of opponent.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
Manchester United manager Ole Gunnar Solskjaer is eager to build his team around midfielder Paul Pogba despite media speculation linking the French World Cup winner with a move away from Old Trafford.
The champions who drew 1-1 at Portsmouth, now have two games remaining to achieve the milestone.
Southampton's Senegal forward Sadio Mane scored the fastest Premier League hat-trick as he broke a 20-year-old record to help them lead 5-1 at home to Aston Villa by halftime on Saturday.
"It is important because he's a special player and special players are always a plus," said Chelsea manager Jose Mourinho.\n
In another match in the English Premiership, Manchester United finished with nine men in a 0-1 defeat to Everton.
Ukraine advanced to the Euro 2020 finals after an impressive first half helped them to a 2-1 home win over Portugal, whose talismanic captain Cristiano Ronaldo scored his 700th career goal.
Manchester United will travel to third-tier MK Dons in the Capital One Cup second round following the draw on Wednesday, the first time they have been involved at this stage of the competition for 19 years.
The 34-year-old is the second-highest scorer for the United States with 30 goals in 95 appearances.
Santini always made it clear that Manchester City's Nicolas Anelka would not be on the list.
Manchester United have signed Dutch international goalkeeper Edwin van der Sar from Premier League rivals Fulham.
Here are five talking points from the weekend's Premier League action:
News of all that's transpired on and off the football field.
Five talking-points from the Premier League weekend after Manchester United extended their winning run against Tottenham Hotspur, Liverpool were made to work hard for their win at Brighton & Hove Albion and Arsenal losing at West Ham United.
Liverpool opened up a seven-point gap at the top of the English Premier League with a 1-0 win at Brighton & Hove Albion on Saturday, while Arsenal's poor away form continued with a 1-0 defeat at West Ham United.
Tottenham Hotspur and Fulham will be favourites to reach the FA Cup fifth round via home replays on Saturday.
Images from the League Cup matches played on Tuesday
Manchester City stumbled to the most unexpected defeat of the Premier League season on Saturday before neighbours Manchester United began their brave new world under Ole Gunnar Solskjaer with a glorious reminder of long-forgotten attacking swagger.
Chelsea's Damien Duff says there is an 80 percent chance he could suffer a recurrence of the dislocated shoulder.
Arsenal will reportedly play Chelsea in a fourth-round Capital One Cup match after winning 4-3 on penalties against West Bromwich Albion on Wednesday at The Hawthorns.
Arsenal beat Fulham 2-0 at the Emirates and Manchester City beat Cardiff City 4-2 at the Etihad before Liverpool could only manage a 2-2 draw at Anfield having trailed 2-0.
The win allowed second-placed Liverpool to close the gap on league leaders Manchester City to two points.
Coach Zico named seven European-based players for matches against Uruguay and the US.
Liverpool needed two extra-time goals to beat NottsCounty 4-2 at Anfield on an eventful night for the Premier League clubs in the League Cup second round on Tuesday.
English champions Manchester United are suddenly in danger of finishing a season empty-handed for the second time in three years.
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