Tottenham Hotspur have the chance to exert psychological pressure on Premier League leaders Chelsea when they open the weekend programme at home to Watford on Saturday.
Manchester United and Manchester City must switch their focus from the Champions League to the Premier League when they meet at Old Trafford on Sunday in a derby that Louis van Gaal says will show whether United are true title contenders.
Samuel Eto'o's hat-trick lifted Chelsea to a 3-1 win over Manchester United on Sunday which all but ended the champions' slim hopes of defending their Premier League title.