Sevilla are favourites to progress to the quarter-finals of the Champions League after holding CSKA Moscow to a 1-1 draw in the first leg of their last-16 clash on Wednesday.
Luis Fabiano's looping header and a Mario Alvarez own goal gave Sevilla a 2-0 win over Getafe in their King's Cup semi-final first-leg on Wednesday.
Juan Mata's deflected late winner gave holders Valencia a 3-2 victory over 2007 winners Sevilla in the first leg of their King's Cup quarter-final on Wednesday.
Goalkeeper Andres Palop emerged as Sevilla's hero by saving three penalties in the shootout to give his side victory over Espanyol.
Holders Barcelona were knocked out of the King's Cup on Wednesday when they won a thrilling last-16 second-leg clash at Sevilla 1-0 but were eliminated on the away goals rule after the tie ended 2-2 on aggregate.
Espanyol fought back from a goal down to beat Sevilla 2-1 at home in the Primera Liga on Sunday, denying the Andalucians first place in the standings.
Sevilla claimed their place in the knockout stage of the Champions League and went top of Group H when they ended Arsenal's unbeaten run this season with a 3-1 comeback win on Tuesday.
UEFA Cup holders Sevilla, rescued by a last-gasp goal in normal time from goalkeeper Andres Palop, kept their defence alive by overcoming Shakhtar Donetsk to reach the quarter-finals on Thursday.