Uruguay's Cristian Rodriguez scored a soft goal in the holders' laboured 1-0 win over outsiders Jamaica when they opened their defence of their Copa America title on Saturday.
In the other match of the night, Jamaica 'keeper blunder hands Paraguay 1-0 win
Mexico scored twice in the final five minutes to beat Uruguay 3-1 in a pulsating Copa America Group C match in which each side had a man sent off on Sunday.
Uruguay are all but assured of a place at the 2014 World Cup finals after Edinson Cavani led the twice champions to a 5-0 away rout of Jordan in the first leg of their qualifying playoff on Wednesday.
An inspired performance from Douglas Costa helped Brazil to a 3-0 win over Peru on Tuesday and lifted them into third place in the South American qualifying group for the 2018 World Cup in Russia.