Wayne Parnell and Imran Tahir took three wickets each as South Africa cruised to an eight-wicket victory over Sri Lanka in the first one-day international in Port Elizabeth on Saturday.
It was an eighth ODI victory in a row for South Africa and an 11th win in succession at home as they showed form in the build-up to the Champions Trophy in England in June.
The dominant home side, playing in a changed pink kit in aid of breast cancer awareness, eased to victory with a full 18 overs to spare as De Villiers led the way with 60 from 61 balls.
Captain Hashim Amla and AB de Villiers led the chase as South Africa cut the deficit to 102 runs in their bid to haul in the West Indies total of 329 before rain ended the second day of the third Test at Newlands on Saturday.
Captain AB de Villiers smashed an unbeaten 101 in his 200th One-Day International to lead South Africa to a five-wicket victory over England and a 3-2 series win at Newlands on Sunday.
Half-centuries from Kraigg Brathwaite and Marlon Samuels steered a battling West Indies to 147 for two at the close on day three of the second Test against South Africa on Sunday.
A century from Hashim Amla laid the foundation for home success on Wednesday as South Africa beat New Zealand by 20 runs to win their opening one-day international at Centurion.
South Africa captain AB de Villiers anchored his side to a six-wicket victory over New Zealand, whose bowling and fielding was far superior to a poor batting performance in the first game of their three match one-day series on Tuesday.
All-rounder Andre Russell smashed a match-winning half-century as West Indies claimed a nail-biting one-wicket victory over South Africa in the fourth one-day international at St George's Park on Sunday.
A venomous spell of fast bowling from Stuart Broad led England to an emphatic seven- wicket win over South Africa in the third on Saturday to clinch the series. Broad's brilliant return of 6-17 on a lively wicket skittled the Proteas for 83 in their second innings on the third day. England reached their modest victory-target of 74 with relative ease as captain Alastair Cook (43) top-scored in guiding them to 77 for three from 22,4 overs under gloomy skies. The tourists now have an unassailable 2-0 lead in the four-match series, with the final game to be played in Pretoria. South Africa bowled out England for 323 in the morning session for a slender first-innings deficit of 10 runs, but were no match for the bounce and movement of a rampant Broad as they crumbled to their second lowest score since returning to international cricket in 1991.