Ousmane Dembele's late strike rescued a 1-1 draw for champions Barcelona at Atletico Madrid but Sevilla moved top with a 1-0 win over Real Valladolid. European champions Real Madrid were humiliated in a 3-0 defeat at Eibar.
Barcelona opened up a four-point gap at the top of La Liga, maintaining their 100 percent start as they cruised to a 3-0 victory at Catalan rivals Girona on Saturday.
La Liga leaders Barcelona beat Real Madrid 1-0 to all but knock their rivals out of the title race on Saturday, while second-placed Atletico Madrid stayed seven points behind the Catalans with a 2-0 win at Real Sociedad on Sunday.
Barcelona have been haunted by their recent failures in the Champions League and there are concerning signs for the Catalans as they prepare for Tuesday's last-16 first leg away to Olympique Lyonnais.
Costa turned Juanfran's low cross into the net in the 69th minute for Atletico's third goal in the first leg of the last 16 tie against third division Lleida but immediately limped to the sidelines. He did return to the pitch, however, and completed the game despite bleeding from his knee.
Barca play their final league La Liga game of the season at Alaves on Sunday before hosting Napoli on Aug. 8 in the second leg of their Champions League last-16 tie.
Barcelona captain Lionel Messi scored two goals and set up two more as the Catalans thrashed Real Valladolid 5-1 to move top of La Liga on Tuesday.
Catalans will have to cope without their inspirational captain Andres Iniesta, the man who has pedigree when it comes to beating the Blues.
Champions Barcelona lost 2-0 at Celta Vigo while Getafe earned an important 2-0 win over Girona in their bid to secure Champions League qualification.
Messi's first act as Barcelona captain was to tell the club's fans at a pre-season friendly in August against Boca Juniors that he and his teammates "will do everything possible so that beautiful and desired cup returns here to the Nou Camp".
Tom Dumoulin of the Netherlands attacked near the foot of the final climb to win the ninth stage of the Tour de France in extreme weather conditions as Alberto Contador pulled out of the race on Sunday.
La Liga champions Barcelona slumped to a shock 2-1 defeat at struggling Leganes and Real Madrid were resoundingly beaten 3-0 by Sevilla on Wednesday as Spain's two biggest clubs lost on the same day for the first time since January, 2015.
Barcelona have been frighteningly good at home this season, scoring 15 goals in three games at the Nou Camp.
Portugal's Rui Costa kept his composure in a tense finale to upset the favourites and clinch the cycling world championships road race on Sunday.
Here are five talking points from the weekend in La Liga:
Real will meet the winners of Thursday's semi between Barcelona and Atletico Madrid in Sunday's showpiece at the King Abdullah Sport City Stadium in Jeddah.
Lukaku, who was signed for around 80 million euros (71.2 million pounds) from Manchester United in the close season, is the club's leading goalscorer in Serie A alongside midfielder Stefano Sensi, with three goals.
Valverde said he was concerned about the team's away form after they were comprehensively beaten 2-0 by promoted Granada
Madrid's trip to San Sebastian was full of intrigue after Barca failed to beat Sevilla and the Catalan side's defender Gerard Pique said the title was now Madrid's for the taking.
According to widespread Spanish media reports, Netherlands coach and former Barca defender Ronald Koeman is set to be named as Setien's successor.
Pochettino picks Barcelona as favourites to win Champions League
British journeyman Stephen Cummings earned South African team MTN-Qhubeka a landmark victory on Mandela Day when he spoiled a French party to take a surprise win in the 14th stage of the Tour de France on Saturday.
With no fans allowed into venues and Real playing their home games at the 6,000-capacity Alfredo Di Stefano stadium while the Santiago Bernabeu is being refurbished, it will be a title race unlike any other.
The FIFA 2022 World Cup will kick-off in Qatar on Sunday, November 20. Here is a list of the 26-man squads playing in the quadrennial global football extravaganza.
Lionel Messi scored a hat-trick as Barcelona clinched a 25th La Liga title on Sunday after winning 4-2 at Deportivo La Coruna despite throwing away a two-goal lead in a thrilling game which also confirmed Depor's relegation.
After almost three weeks of action-packed racing the minor podium places in the Tour de France are likely to be decided in Saturday's final time trial.
Real Madrid are on the verge of reaching the King's Cup quarter-finals after winning 3-0 at Numancia on Thursday while holders Barcelona still have work to do after being held to a 1-1 draw at Celta Vigo.
Barcelona's players will bear the city's name on the back of their shirts in tribute to the victims of Thursday's deadly attack in the Catalan capital when they play Real Betis in La Liga on Sunday, the club said in a statement.
A round-up of Tuesday's action in the UEFA Champions League.
Calling his side 'weak', 'inconsistent' and 'very easy to score against', Lionel Messi called for urgent changes
Barcelona rode their luck to come from behind and win 2-1 at Real Sociedad on Saturday, continuing to banish their awful record in San Sebastian and maintaining their perfect start to the La Liga season.
A round-up of Wednesday's action in the UEFA Champions League.
Runaway Premier League leaders Manchester City beat champions Chelsea 1-0 at the Etihad Stadium on Sunday to extend their lead to 18 points and leave the London side further adrift from the Champions League qualification spots.
Messi scored twice and created goals for Arturo Vidal and Luis Suarez as champions Barca moved top of the table with 22 points from 10 matches.
Marco Asensio followed up his brilliant late goal in Sunday's first leg with a stunning effort from 30 metres in the fourth minute that proved a punishing blow for the Catalans.
Lionel Messi created a goal and scored another as Barcelona came from behind to beat struggling Rayo Vallecano 3-1 at home on Saturday and stay seven points clear at the top of La Liga.
Real Madrid ended their long wait for a La Liga victory by beating Real Valladolid 2-0 on Saturday with two late goals in interim coach Santiago Solari's first home game in charge of the struggling European champions.
The historic rivals will meet again twice in August in the Spanish Super Cup and this International Champions Cup match set the entertainment bar high, with Barcelona maintaining their 100 per cent record in pre-season.
Messi has been linked with a move away from the Camp Nou at the end of the season after he caused a stir by criticising the club's sporting director Eric Abidal
