The Catalans will not just be looking to extend their domestic hegemony, though, as they have spent a combined 250 million euros ($280 million) on a renewed bid to win the Champions League.
The injury will put Valencia midfielder Edu out of action for most of the season.
Check out the top footballers of the weekend...
Cristiano Ronaldo scored twice as Real Madrid beat Athletic Bilbao 4-2 in a thrilling match at the Bernabeu to move within a point of leaders Barcelona in La Liga on Saturday.
Ferrari's Fernando Alonso rewrote the Formula One form book by winning his home Spanish Grand Prix for the second time on Sunday.
The 22-year-old left winger has been the outstanding Spanish player in the Primera Liga this season.
Britain number one Andy Murray has overtaken 14-time Grand Slam champion Rafael Nadal to claim the third spot in the ATP world rankings.
Manchester United are satisfied with their transfer business and under no pressure to sign a fourth player in the current window, manager Jose Mourinho said.
A 5-1 victory enabled them retain the top spot in the Primera Liga.
Barcelona midfielder Xavi has withdrawn from the Spain squad to play Uruguay this week because of a hamstring problem, the Spanish football federation (RFEF) said on Monday.
The Indian contingent's schedule at the Rio Olympics for Thursday.
Qatari-backed Paris St Germain's mission to be considered one of Europe's top clubs faces its toughest test yet when they host Barcelona in an intriguing Champions League quarter-final first leg on Tuesday.
Real Madrid's faint hopes of retaining their La Liga title receded further when Kaka was sent off and they drew 0-0 at struggling Osasuna on Saturday, while Valencia climbed to seventh with a 2-0 win over Sevilla.
Two goals from Thomas Mueller and one from substitute Mario Goetze helped Bayern Munich kick off their Champions League campaign with an impressive 3-0 victory over Olympiakos.
Beckham was whistled and jeered by Valencia fans for a mediocre display during a pre-season friendly.\n\n
While it is unfair to blame the Wales winger for all of Real's recent woes, it cannot be denied that he appears to be struggling for form and confidence.
Paris St Germain striker Zlatan Ibrahimovic was suspended for two games by UEFA on Wednesday for his sending off in the Champions League last 16 first leg match with Valencia, the governing body said.
Reigning champions Real Madrid took advantage of Valencia's defeat against Deportivo to move up to second.
Jorge Lorenzo's celebration of his MotoGP world title on his home island of Mallorca on Thursday was interrupted unexpectedly when the Spanish Yamaha rider suffered what appeared to be minor burns to his leg from a motorcycle.
Paris St Germain's 2-1 Champions League win at Valencia on Tuesday is proof that the big-spending Ligue 1 club have become a force in Europe but they should not get carried away, according to director of football Leonardo.
Holders Barcelona reached the King's Cup semi-finals with a 2-0 win over Espanyol on Thursday to overcome a first-leg deficit on a night when new signing Philippe Coutinho made his debut.
Lionel Messi scored in his 12th consecutive La Liga game to help leaders Barcelona earn a 1-1 draw at Valencia, allowing second-placed Atletico Madrid to close to within nine points after a 1-0 win over Real Betis on Sunday.
Lionel Messi fired Barcelona into the last 16 of the Champions League with two goals in their 3-0 victory at Spartak Moscow on Tuesday but holders Chelsea are walking a tightrope after a crushing defeat by Juventus.
A summary of Saturday night's matches in the Euro 2020 qualifiers.
Atletico Madrid took full advantage of Barcelona's defeat at Real Sociedad and closed to within eight points of the La Liga leaders when Adrian and Koke struck in a 2-0 win at home to Levante on Sunday.
La Liga champions Real Madrid dropped points at home for the second game running when they drew 1-1 with Levante on Saturday, with Gareth Bale squandering a series of chances and Marcelo getting sent off late on.
A summary of Wednesday night's matches inthe UEFA Champions League.
Real Madrid moved four points clear of Barcelona at the top of La Liga with Cristiano Ronaldo scoring either side of a Gareth Bale strike in a 3-0 win at Getafe on Sunday.
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Real Madrid took full advantage of Barcelona's shock defeat at Real Valladolid with a 3-0 home win over 10-man Levante on Sunday that put Carlo Ancelotti's in-form side three points clear at the top of La Liga.
The Spanish League leaders slipped to a 2-0 defeat at home to Real Mallorca.
Columbian pop singer, Shakira was spotted in the crowds during the King's Cup final between Barcelona and Real played at Valencia's Mestalla stadium on Wednesday.
Robin van Persie's late penalty earned below-par Manchester United a 2-1 victory over 10-man Liverpool in an emotionally-charged Premier League clash at Anfield and champions Manchester City were held to a 1-1 home draw by Arsenal on Sunday.
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